Duane retraction syndrome
Findings
No curated finding names Duane retraction syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Duane retraction syndrome (DRS) is a congenital form of strabismus characterized by horizontal eye movement limitation, globe retraction and palpebral fissure narrowing in attempted adduction. It is caused by a failure of development of the abducens nerve and can lead to amblyopia.
Definition from the Mondo Disease Ontology (MONDO:0007473), read 2026-09-29. CC BY 4.0.
Features
62 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormality of eye movementHPOHP:0000496
- Very frequent (80% to 99% of cases)
- Duane anomalyHPOHP:0009921
- Very frequent (80% to 99% of cases)
- Oculomotor apraxiaHPOHP:0000657
- Very frequent (80% to 99% of cases)
- Oculomotor nerve palsyHPOHP:0012246
- Very frequent (80% to 99% of cases)
- Short palpebral fissureHPOHP:0012745
- Very frequent (80% to 99% of cases)
- StrabismusHPO · MondoHP:0000486
- Very frequent (80% to 99% of cases)
- Abnormal vertebral segmentation and fusionHPOHP:0005640
- Frequent (30% to 79% of cases)
- Anteverted naresHPOHP:0000463
- Frequent (30% to 79% of cases)
- BlepharophimosisHPOHP:0000581
- Frequent (30% to 79% of cases)
- Deeply set eyeHPOHP:0000490
- Frequent (30% to 79% of cases)
- Impaired ocular abductionHPOHP:0000634
- Frequent (30% to 79% of cases)
- Impaired ocular adductionHPOHP:0000542
- Frequent (30% to 79% of cases)
Show the remaining 50
- Low posterior hairlineHPOHP:0002162
- Frequent (30% to 79% of cases)
- Sensorineural hearing impairmentHPOHP:0000407
- Frequent (30% to 79% of cases)
- Abnormal cardiovascular system morphologyHPOHP:0030680
- Occasional (5% to 29% of cases)
- Abnormal pinna morphologyHPOHP:0000377
- Occasional (5% to 29% of cases)
- Abnormal pupil morphologyHPOHP:0000615
- Occasional (5% to 29% of cases)
- Abnormal vertebral body morphologyHPOHP:0003312
Genes
3 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
Where it sits
Other names
5 names
Resolves to: Duane retraction syndrome
- Also called
- DRSDuane syndromeDuane's syndromeDURSStilling-Turk-Duane syndrome