congenital vitamin K-dependent coagulation factors deficiency
MONDO:0015722Mondo
Findings
No curated finding names congenital vitamin K-dependent coagulation factors deficiency yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Congenital vitamin K-dependent coagulation factors deficiency involving multiple coagulation factors.
Definition from the Mondo Disease Ontology (MONDO:0015722), read 2026-09-29. CC BY 4.0.
Features
31 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal bleedingHPOHP:0001892
- Frequent (30% to 79% of cases)
- Bruising susceptibilityHPOHP:0000978
- Frequent (30% to 79% of cases)
- Decreased level of heparin co-factor IIHPOHP:0040226
- Frequent (30% to 79% of cases)
- Prolonged partial thromboplastin timeHPOHP:0003645
- Frequent (30% to 79% of cases)
- Prolonged prothrombin timeHPOHP:0008151
- Frequent (30% to 79% of cases)
- Reduced factor IX activityHPOHP:0011858
- Frequent (30% to 79% of cases)
- Reduced factor VII activityHPOHP:0008169
- Frequent (30% to 79% of cases)
- Reduced factor X activityHPOHP:0008321
- Frequent (30% to 79% of cases)
- Reduced protein C activityHPOHP:0005543
- Frequent (30% to 79% of cases)
- Reduced protein S activityHPOHP:0004855
- Frequent (30% to 79% of cases)
- Angioid streaksHPOHP:0001102
- Occasional (5% to 29% of cases)
- AtherosclerosisHPOHP:0002621
- Occasional (5% to 29% of cases)
Show the remaining 19
- CephalohematomaHPOHP:0012541
- Occasional (5% to 29% of cases)
- Cutis laxaHPOHP:0000973
- Occasional (5% to 29% of cases)
- EcchymosisHPOHP:0031364
- Occasional (5% to 29% of cases)
- Epiphyseal stipplingHPOHP:0010655
- Occasional (5% to 29% of cases)
- EpistaxisHPOHP:0000421
- Occasional (5% to 29% of cases)
- Hypoplasia of the nasal boneHPOHP:0004646
- Occasional (5% to 29% of cases)
Where it sits
Other names
2 names
Resolves to: congenital vitamin K-dependent coagulation factors deficiency
- Also called
- congenital vitamin K-dependent coagulation factors combined deficiencyvitamin K-dependent clotting factors, combined deficiency of