congenital factor X deficiency
Findings
No curated finding names congenital factor X deficiency yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Congenital factor X deficiency is an inherited bleeding disorder with a decreased antigen and/or activity of factor X (FX) and characterized by mild to severe bleeding symptoms.
Definition from the Mondo Disease Ontology (MONDO:0009212), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal recessive inheritance
HPO, annotations 2026-09-02
Features
19 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Prolonged bleeding after surgeryHPOHP:0004846
- 1 of 1 reported patient
- Very frequent (80% to 99% of cases)
- Prolonged prothrombin timeHPOHP:0008151
- 1 of 1 reported patient
- Obligate (100% of cases)
- Reduced factor X activityHPOHP:0008321
- 1 of 1 reported patient
- Obligate (100% of cases)
- Prolonged bleeding after dental extractionHPOHP:0006298
- Very frequent (80% to 99% of cases)
- EpistaxisHPOHP:0000421
- Frequent (30% to 79% of cases)
- Gingival bleedingHPOHP:0000225
- Frequent (30% to 79% of cases)
Show the remaining 7
- Joint hemorrhageHPOHP:0005261
- Occasional (5% to 29% of cases)
- MenorrhagiaHPOHP:0000132
- Occasional (5% to 29% of cases)
- Oral cavity bleedingHPOHP:0030140
- Occasional (5% to 29% of cases)
- Post-partum hemorrhageHPOHP:0011891
- Occasional (5% to 29% of cases)
- Spontaneous hematomasHPOHP:0007420
- Occasional (5% to 29% of cases)
- HemoperitoneumHPOHP:0011854
- Very rare (1% to 4% of cases)
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- F10HGNC:3528
- Definitive · Ambry Genetics · Autosomal recessive · 2018
- Definitive · ClinGen · Autosomal recessive · 2019
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal recessive · 2020
- Strong · PanelApp Australia · Autosomal recessive · 2025
- Supportive · Orphanet · Autosomal recessive · 2021
Where it sits
Other names
3 names
Resolves to: congenital factor X deficiency
- Also called
- congenital Stuart factor deficiencyhereditary Factor X deficiencyStuart-Prower factor deficiency