classic Hodgkin lymphoma
Findings
No curated finding names classic Hodgkin lymphoma yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Classical Hodgkin lymphoma (CHL) is a B-cell lymphoma characterized histologically by the presence of large mononuclear Hodgkin cells and multinucleated Reed-Sternberg (HRS) cells.
Definition from the Mondo Disease Ontology (MONDO:0009348), read 2026-09-29. CC BY 4.0.
Features
33 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Cellular immunodeficiencyHPOHP:0005374
- Very frequent (80% to 99% of cases)
- FatigueHPOHP:0012378
- Very frequent (80% to 99% of cases)
- LymphadenopathyHPOHP:0002716
- Very frequent (80% to 99% of cases)
- LymphomaHPOHP:0002665
- Very frequent (80% to 99% of cases)
- AnorexiaHPOHP:0002039
- Frequent (30% to 79% of cases)
- Back painHPOHP:0003418
- Frequent (30% to 79% of cases)
- Chest painHPOHP:0100749
- Frequent (30% to 79% of cases)
- CoughHPOHP:0012735
- Frequent (30% to 79% of cases)
- Elevated circulating C-reactive protein concentrationHPOHP:0011227
- Frequent (30% to 79% of cases)
- FeverHPOHP:0001945
- Frequent (30% to 79% of cases)
- HyperhidrosisHPOHP:0000975
- Frequent (30% to 79% of cases)
- Night sweatsHPOHP:0030166
- Frequent (30% to 79% of cases)
Show the remaining 21
- Poor appetiteHPOHP:0004396
- Frequent (30% to 79% of cases)
- PruritusHPOHP:0000989
- Frequent (30% to 79% of cases)
- Weight lossHPOHP:0001824
- Frequent (30% to 79% of cases)
- Hodgkin lymphomaHPOHP:0012189
- 3 of 7 reported patients
- AnemiaHPOHP:0001903
- Occasional (5% to 29% of cases)
- AtaxiaHPOHP:0001251
- Occasional (5% to 29% of cases)
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- KLHDC8BHGNC:28557
- Limited · Ambry Genetics · Autosomal dominant · 2024
- Limited · Labcorp Genetics (formerly Invitae) · Unknown · 2020
Where it sits
- A kind of
Other names
3 names
Resolves to: classic Hodgkin lymphoma
- Also called
- classic Hodgkin diseaseclassical Hodgkin lymphomaclassical Hodgkin's lymphoma