bronchiolitis obliterans syndrome
Findings
No curated finding names bronchiolitis obliterans syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A lung disorder that is mainly associated with chronic allograft dysfunction after lung transplantation and that is characterized by inflammation and fibrosis of bronchiolar walls that reduce the diameter of the bronchioles and result in progressive and irreversible airflow obstruction.
Definition from the Mondo Disease Ontology (MONDO:0015265), read 2026-09-29. CC BY 4.0.
Features
16 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Airway obstructionHPOHP:0006536
- Very frequent (80% to 99% of cases)
- Bronchiolitis obliteransHPOHP:0011946
- Very frequent (80% to 99% of cases)
- CoughHPOHP:0012735
- Very frequent (80% to 99% of cases)
- Decreased forced expiratory flow 25-75%HPOHP:0032359
- Very frequent (80% to 99% of cases)
- DyspneaHPOHP:0002094
- Very frequent (80% to 99% of cases)
- HypoxemiaHPOHP:0012418
- Very frequent (80% to 99% of cases)
- Reduced FEV1/FVC ratioHPOHP:0030877
- Very frequent (80% to 99% of cases)
- Reduced forced expiratory volume in one secondHPOHP:0032342
- Very frequent (80% to 99% of cases)
- Reduced forced vital capacityHPOHP:0032341
- Very frequent (80% to 99% of cases)
- Decreased DLCOHPOHP:0045051
- Frequent (30% to 79% of cases)
- Nonproductive coughHPOHP:0031246
- Frequent (30% to 79% of cases)
- PneumoniaHPOHP:0002090
- Frequent (30% to 79% of cases)
Show the remaining 4
- Respiratory tract infectionHPOHP:0011947
- Frequent (30% to 79% of cases)
- AutoimmunityHPOHP:0002960
- Occasional (5% to 29% of cases)
- BronchiectasisHPOHP:0002110
- Occasional (5% to 29% of cases)
- Ground-glass opacificationHPOHP:0025179
- Very rare (1% to 4% of cases)
Where it sits
Other names
4 names
Resolves to: bronchiolitis obliterans syndrome
- Also called
- BOOPconstrictive bronchiolitisorganised pneumoniaorganized pneumonia