FIA-induced writhing reaction

decreases

The induction of the writhing reaction was also inhibited by intravenous preadministration of sodium ascorbate (SAs) in saline

PMID:10077427 · one of two readings recorded this

FIA-induced writhing reaction

decreases

The FIA emulsion-induced writhing reaction was found to be remarkably inhibited by preadministration of oral indomethacin, a non-steroidal anti-inflammatory and analgesic drug

PMID:10077427 · one of two readings recorded this

Freund's incomplete adjuvant-induced writhing reaction in mice

decreases

Not recorded as a finding: this platform holds no node for the endpoint

The induction of the writhing reaction was also inhibited by intravenous preadministration of sodium ascorbate (SAs) in saline.

PMID:10077427 · both readings recorded this

writhing reaction induced by FIA+SAs emulsion

decreases

Furthermore, this writhing reaction induced by FIA+SAs emulsion was also inhibited by preadministraion of SAs itself as well as indomethacin

PMID:10077427 · one of two readings recorded this

writhing reaction when sodium ascorbate added to FIA, higher concentrations

increases

At lower concentrations SAs functioned as a suppressor of the writhing reaction, while at concentrations higher than about 1 mg/50 microl/mouse it acted as an enhancer of the reaction

PMID:10077427 · one of two readings recorded this

writhing reaction when sodium ascorbate added to FIA, lower concentrations

decreases

At lower concentrations SAs functioned as a suppressor of the writhing reaction, while at concentrations higher than about 1 mg/50 microl/mouse it acted as an enhancer of the reaction

PMID:10077427 · one of two readings recorded this

ascorbate concentration in plasma and SVCT1-predominant tissues

increases

Compared with males, females had lower ascorbate excretion and ascorbate:creatinine ratio in urine and had higher ascorbate concentrations in plasma and SVCT1-predominant tissues

PMID:15333707 · one of two readings recorded this

hepatic gulonolactone oxidase mRNA and activity

no effect

Hepatic gulonolactone oxidase mRNA and activity levels did not differ with genotype or gender, indicating no differences in ascorbate synthesis

PMID:15333707 · one of two readings recorded this

spleen ascorbate concentration, male vs female

increases

SVCT2 contributed to a gender effect in spleen because males had higher spleen ascorbate concentration than females in wild-type but not in Slc23a2+/- mice

PMID:15333707 · one of two readings recorded this

SVCT1 expression and ascorbate concentration in SVCT1-predominant organs

no effect

The SVCT isoforms appear to function independently of one another because SVCT1 expression and ascorbate concentrations in SVCT1-predominant organs were not affected by SVCT2 deficiency

PMID:15333707 · one of two readings recorded this

SVCT2 mRNA level

decreases

Slc23a2+/- mice had low SVCT2 but normal SVCT1 messenger RNA (mRNA) levels, which did not differ between genders

PMID:15333707 · one of two readings recorded this

tissue ascorbate concentration in SVCT2-predominant tissues

decreases

Ascorbate concentrations were lower in Slc23a2+/- than Slc23a2+/+ mice in tissues where SVCT2 was the main isoform

PMID:15333707 · one of two readings recorded this

urinary ascorbate excretion and ascorbate:creatinine ratio

decreases

Compared with males, females had lower ascorbate excretion and ascorbate:creatinine ratio in urine and had higher ascorbate concentrations in plasma and SVCT1-predominant tissues

PMID:15333707 · one of two readings recorded this

MDC viability under H2O2 stress

increases

we found that the viability of MDCs exposed to a cytotoxic concentration of H2O2 was higher after preincubation with 0.1 mM ASC (2.6-fold), 10 ng/ml bFGF (2.9-fold), or 20 ng/ml bFGF (3.5-fold) than that after exposure to H2O2 only

PMID:17219780 · one of two readings recorded this

MDC viability under H2O2 stress

increases

we found that the viability of MDCs exposed to a cytotoxic concentration of H2O2 was higher after preincubation with 0.1 mM ASC (2.6-fold), 10 ng/ml bFGF (2.9-fold), or 20 ng/ml bFGF (3.5-fold) than that after exposure to H2O2 only

PMID:17219780 · one of two readings recorded this

MDC viability under H2O2 stress

increases

we found that the viability of MDCs exposed to a cytotoxic concentration of H2O2 was higher after preincubation with 0.1 mM ASC (2.6-fold), 10 ng/ml bFGF (2.9-fold), or 20 ng/ml bFGF (3.5-fold) than that after exposure to H2O2 only

PMID:17219780 · one of two readings recorded this

viability of rat muscle-derived cells exposed to a cytotoxic concentration of H2O2 after 24-h preincubation

increases, 2.6-fold higher viability with 0.1 mM ASC than H2O2 only

Not recorded as a finding: this platform holds no node for the endpoint

In addition, we found that the viability of MDCs exposed to a cytotoxic concentration of H2O2 was higher after preincubation with 0.1 mM ASC (2.6-fold), 10 ng/ml bFGF (2.9-fold), or 20 ng/ml bFGF (3.5-fold) than that after exposure to H2O2 only.

PMID:17219780 · both readings recorded this

CD71 (transferrin receptor) cell-surface expression on neuroblastoma cells

decreases

Not recorded as a finding: expression readout, not receptor/enzyme activity; no mechanism predicate applies, and no outcome node exists for receptor expression

Sodium ascorbate decreased the expression of CD71 and caused cell death within 24 h.

PMID:17760959 · one of two readings recorded this

cell survival (trypan blue exclusion, EC50)

decreases, EC50 < 2 mM in all five cell lines

Vitamin C concentrations causing a 50% decrease in cell survival after 24 hours (EC50 values, table 1) were less than 2 mM for all five cell lines, as assessed by trypan blue exclusion method.

PMID:17760959 · one of two readings recorded this

intracellular iron level

decreases

As shown in fig. vitamin C significantly reduced intracellular iron levels in a dose-dependent manner.

PMID:17760959 · one of two readings recorded this

mitochondrial transmembrane potential

decreases

Treatment with vitamin C induced depolarization of the mitochondrial transmembrane potential in all neuroblastoma cell lines investigated (fig., panel A2, A4, panel B2, B4).

PMID:17760959 · one of two readings recorded this

transferrin receptor (CD71) surface expression

decreases

Sodium ascorbate decreased the expression of CD71 and caused cell death within 24 h.

PMID:17760959 · one of two readings recorded this

adhesive failure mode, all-in-one vs two-step

increases, p = 0.015

All-in-one groups had significantly more adhesive failures than two-step adhesive groups (p=0.015)

PMID:23713808 · one of two readings recorded this

adhesive failure, pulp horn vs peripheral position

increases, p = 0.004

The odds of adhesive failure were higher at the pulp horn position than the peripheral position (p=0.004)

PMID:23713808 · one of two readings recorded this

microshear bond strength and failure mode after sodium perborate bleaching

no effect

Sodium perborate bleaching of dentin had no effect on MSBS or mode of failure for either two-step or all-in-one self-etching adhesives

PMID:23713808 · one of two readings recorded this

microshear bond strength, between treatment groups

no effect

There were no significant differences between the treatment types/groups

PMID:23713808 · one of two readings recorded this

microshear bond strength, center and pulp horn vs peripheral

decreases, p = 0.001

For the all-in-one adhesive, MSBSs at the center and pulp horn positions were significantly lower than the peripheral positions (p<0.001)

PMID:23713808 · one of two readings recorded this

microshear bond strength (MSBS) of resin composite to sodium perborate-bleached dentin

no effect

Not recorded as a finding: this platform holds no node for the endpoint

There were no significant differences between the treatment types/groups.

PMID:23713808 · both readings recorded this

microshear bond strength, two-step vs all-in-one adhesive

increases, p = 0.028

MSBSs were significantly higher for two-step self-etching adhesive compared with all-in-one self-etching adhesive (p=0.028)

PMID:23713808 · one of two readings recorded this

hybrid layer and resin tag formation and microtensile bond strength

decreases

Tooth bleaching with CP or HP impairs the formation of the hybrid layer and resin tags and reduces the microtensile bond strength

PMID:23848067 · one of two readings recorded this

hybrid layer + tag formation

increases

hybrid layer + tag formation (in micrometers) were G C, 13.27 Aa; G SA, 11.85 Ba; G CP, 6.84 Bb; G CP+SA, 9.02 Ab; G HP, 7.28 Bb; and G HP+SA, 9.22 Ab

PMID:23848067 · one of two readings recorded this

hybrid layer thickness and resin tag length by optic microscopy; microtensile bond strength to dentin (MPa)

increases

Not recorded as a finding: this platform holds no node for the endpoint

Statistically, the use of SA significantly increases the hybrid layer thickness and resin tag length.

PMID:23848067 · one of two readings recorded this

hybrid layer thickness and resin tag length of bleached dentin, optic microscopy after Brown & Brenn staining

increases

Not recorded as a finding: this platform holds no node for the endpoint

Statistically, the use of SA significantly increases the hybrid layer thickness and resin tag length.

PMID:23848067 · one of two readings recorded this

hybrid layer thickness and resin tag length

increases

Statistically, the use of SA significantly increases the hybrid layer thickness and resin tag length

PMID:23848067 · one of two readings recorded this

microtensile bond strength, hydrogen peroxide-bleached

no effect

The microtensile bond strength values for carbamide peroxide increased, but the microtensile bond strength for hydrogen peroxide was not affected

PMID:23848067 · one of two readings recorded this

microtensile bond strength

modulates

bond strength results (in MPa) were G C, 49.5 Aa; G SA, 51.7 Aa; G CP, 37.16 Bb; G CP+SA, 47.69 Aa; G HP, 32.39 Ab; and G HP+SA, 39.67 Ab

PMID:23848067 · one of two readings recorded this

elastase, protease and haemolysin virulence factor activities

decreases

The influence of sub-MIC of sodium ascorbate on virulence factors was also determined and ascorbate treatment led to significant depression of elastase, protease and haemolysin activities.

PMID:25175797 · one of two readings recorded this

expression of QS regulatory genes lasI, lasR, rhlI, rhlR, pqsR and pqsA

Not recorded as a finding: sentence reports gene expression was repressed 'compared to untreated' PAO1 without naming sodium ascorbate as the acting agent in the same clause, so the quote does not self-support the claim

Expression of QS regulatory genes, lasI, lasR, rhlI, rhlR, pqsR and pqsA, was repressed compared to untreated Ps. aeruginosa PAO1, confirming that ascorbate QS inhibition works on gene expression at the molecular level.

PMID:25175797 · one of two readings recorded this

expression of QS regulatory genes (lasI, lasR, rhlI, rhlR, pqsR, pqsA)

Expression of QS regulatory genes, lasI, lasR, rhlI, rhlR, pqsR and pqsA, was repressed compared to untreated Ps. aeruginosa PAO1, confirming that ascorbate QS inhibition works on gene expression at the molecular level.

PMID:25175797 · one of two readings recorded this

expression of quorum-sensing regulatory genes lasI, lasR, rhlI, rhlR, pqsR and pqsA in Pseudomonas aeruginosa PAO1

decreases

Not recorded as a finding: six genes reported as one repressed group with no single-gene object span, and transcript-level gene expression is not a mechanism_claims predicate (inhibits/activates describe protein activity, not expression)

Expression of QS regulatory genes, lasI, lasR, rhlI, rhlR, pqsR and pqsA, was repressed compared to untreated Ps. aeruginosa PAO1, confirming that ascorbate QS inhibition works on gene expression at the molecular level.

PMID:25175797 · one of two readings recorded this

expression of quorum-sensing regulatory genes lasI, lasR, rhlI, rhlR, pqsR and pqsA

decreases

Expression of QS regulatory genes, lasI, lasR, rhlI, rhlR, pqsR and pqsA, was repressed compared to untreated Ps. aeruginosa PAO1, confirming that ascorbate QS inhibition works on gene expression at the molecular level.

PMID:25175797 · one of two readings recorded this

pyocyanin production, biofilm formation, and motility of Pseudomonas aeruginosa PAO1

Not recorded as a finding: reported as one agentless-passive clause covering three distinct virulence phenotypes with mixed/unstated direction on motility, not anchorable to a single named protein or compound object for mechanism_claims

In addition, inhibition of pyocyanin production, attenuation of biofilm formation and alteration of Pseudomonas motility was observed.

PMID:25175797 · one of two readings recorded this

pyocyanin production, biofilm formation and Pseudomonas motility

Not recorded as a finding: sentence reporting this finding is an agentless passive ('was observed') that does not name sodium ascorbate as the acting agent, so it cannot anchor a claim on its own

In addition, inhibition of pyocyanin production, attenuation of biofilm formation and alteration of Pseudomonas motility was observed.

PMID:25175797 · one of two readings recorded this

pyocyanin production, biofilm formation, and Pseudomonas motility

In addition, inhibition of pyocyanin production, attenuation of biofilm formation and alteration of Pseudomonas motility was observed.

PMID:25175797 · one of two readings recorded this

quorum sensing signalling molecule concentration (C4-HSL, 3-oxo-C12-HSL)

decreases

Sub-MICs of sodium ascorbate resulted in significant reduction of the signalling molecules C4-HSL and 3-oxo-C12-HSL (P < 0·01).

PMID:25175797 · one of two readings recorded this

signalling molecules C4-HSL and 3-oxo-C12-HSL concentration, reporter strain assay

decreases

Sub-MICs of sodium ascorbate resulted in significant reduction of the signalling molecules C4-HSL and 3-oxo-C12-HSL (P < 0·01).

PMID:25175797 · one of two readings recorded this

virulence factor activity (elastase, protease, haemolysin)

decreases

The influence of sub-MIC of sodium ascorbate on virulence factors was also determined and ascorbate treatment led to significant depression of elastase, protease and haemolysin activities.

PMID:25175797 · one of two readings recorded this

BL6 melanoma growth in vivo

decreases

Supplementary dietary ascorbate increased liver and tumor ascorbic acid levels and also reduced the growth of BL6 melanomas transplanted in C57 mice

PMID:2703917 · one of two readings recorded this

cellular ascorbic acid levels, BL6 versus LLCMK cells

no effect

Ascorbic acid levels in both cell types were very similar

PMID:2703917 · one of two readings recorded this

growth of BL6 melanomas transplanted in C57 mice, and in vitro growth of BL6 and LLCMK cells

decreases

Not recorded as a finding: this platform holds no node for the endpoint

Supplementary dietary ascorbate increased liver and tumor ascorbic acid levels and also reduced the growth of BL6 melanomas transplanted in C57 mice.

PMID:2703917 · one of two readings recorded this

growth of BL6 melanomas transplanted in C57 mice; in vitro growth of BL6 and LLCMK cells; liver and tumor ascorbic acid levels

decreases

Not recorded as a finding: this platform holds no node for the endpoint

Supplementary dietary ascorbate increased liver and tumor ascorbic acid levels and also reduced the growth of BL6 melanomas transplanted in C57 mice.

PMID:2703917 · one of two readings recorded this

in vitro cell growth

decreases

Ascorbate addition at levels of up to 200 micrograms/ml was found to inhibit the in vitro growth of BL6 cells but not of LLCMK cells

PMID:2703917 · one of two readings recorded this

in vitro cell growth

no effect

Ascorbate addition at levels of up to 200 micrograms/ml was found to inhibit the in vitro growth of BL6 cells but not of LLCMK cells

PMID:2703917 · one of two readings recorded this

liver ascorbic acid level

decreases

The presence of tumors was found to reduce liver ascorbic acid levels in mice

PMID:2703917 · one of two readings recorded this

liver ascorbic acid level

increases

Supplementary dietary ascorbate increased liver and tumor ascorbic acid levels and also reduced the growth of BL6 melanomas transplanted in C57 mice

PMID:2703917 · one of two readings recorded this

tumor ascorbic acid level

increases

Supplementary dietary ascorbate increased liver and tumor ascorbic acid levels and also reduced the growth of BL6 melanomas transplanted in C57 mice

PMID:2703917 · one of two readings recorded this

cytotoxic effect of methotrexate and DTIC on neuroblastoma cells

decreases

Sodium L-ascorbate did not enhance the effect of vincristine, 6-thioguanine, or 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) except at higher drug doses and it reduced the cytotoxic effect of methotrexate and 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC) on NB cells.

PMID:284405 · one of two readings recorded this

growth inhibition (cell death and reduced division) of neuroblastoma vs glioma cells

increases

Sodium L-ascorbate at nonlethal concentrations potentiated the effect of 5-fluorouracil (FUra), x-irradiation, bleomycin, RO20-1724, prostaglandin E1, and sodium butyrate on NB cells but did not produce such an effect on glioma cells.

PMID:284405 · one of two readings recorded this

dentin surface crystal deposition (SEM/EDS)

increases

The portion of the dentin surface filled with the crystals and the size of crystal increased in the dentin surface after 72 hours of application time of 10% SA solution.

PMID:29109820 · one of two readings recorded this

microtensile bond strength (µTBS, MPa) of composite resin to bleached dentin at varying sodium ascorbate application times

no effect

Not recorded as a finding: this platform holds no node for the endpoint

No significant difference was observed among the control group and subgroups DB, SA 5 m, SA 10 m, SA 30 m, SA 1 h, SA 24 h, and SA 48 h (p > 0.05).

PMID:29109820 · one of two readings recorded this

microtensile bond strength (µTBS) of composite resin to bleached dentin

no effect

No significant difference was observed among the control group and subgroups DB, SA 5 m, SA 10 m, SA 30 m, SA 1 h, SA 24 h, and SA 48 h (p > 0.05).

PMID:29109820 · one of two readings recorded this

pushout bond strength (MPa) of a fiber post luted to radicular dentin after irrigation with 10% sodium ascorbate versus other collagen cross-linkers

increases, n = 28

Not recorded as a finding: this platform holds no node for the endpoint

There was a significant increase in the mean push out bond strength as compared to Group 1 (control group) (P < 0.001).

PMID:29628656 · one of two readings recorded this

pushout bond strength of fiber post luted to radicular dentin after irrigation with 10% sodium ascorbate, 10% hesperidin, 1% riboflavin 5-phosphate or normal saline, by Universal Testing Machine

increases

Not recorded as a finding: this platform holds no node for the endpoint

All collagen cross-linkers so used, increased the bond strength.

PMID:29628656 · one of two readings recorded this

pushout bond strength of fiber post to radicular dentin

increases, n = 28

There was a significant increase in the mean push out bond strength as compared to Group 1 (control group) (P < 0.001).

PMID:29628656 · one of two readings recorded this

antibody structural integrity (SDS-PAGE/autoradiography)

increases

These findings suggest that 211At‐anti‐TF mAb in PBS was disrupted by the radionuclide, and 0.6% and 1.2% SA protected the immunoconjugates from antibody denaturation.

PMID:33606344 · one of two readings recorded this

antitumor activity of 211At-labeled anti-tissue factor antibody in a high TF-expressing gastric cancer xenograft model

increases

Not recorded as a finding: the compound was a reagent, not an exposure

In a high TF-expressing gastric cancer xenograft model, 211 At-anti-TF mAb in 1.2% SA exerted a significantly greater antitumor effect than nonprotected 211 At-anti-TF mAb.

PMID:33606344 · one of two readings recorded this

antitumor effect in gastric cancer xenografts (tumour volume)

increases, p = 0.0045

In the 44As3 xenograft model with high TF expression, 211At‐anti‐TF mAb eluted in PBS containing 1.2% SA exerted a significantly greater antitumor effect than the astatinated anti‐TF mAb in PBS (P =.0045).

PMID:33606344 · one of two readings recorded this

body weight loss (toxicity)

no effect, 5.65 ± 1.39% at 2 days, transient

Although relative body weight loss reached 5.65 ± 1.39% at 2 days after administration of 1.2% SA in PBS, the loss was transient.

PMID:33606344 · one of two readings recorded this

adult mosquito mortality

unclear

Four of the six volatile compounds increased mortality in at least one species.

PMID:35861727 · one of two readings recorded this

mosquito feeding/attraction to the bait

increases

Addition of anisaldehyde also significantly increased An. stephensi feeding rates on the SA-ATSB, though mosquitoes will avoid the toxic bait if a nontoxic sugar source is available.

PMID:35861727 · one of two readings recorded this

colour change (ΔEab, ΔE00, ΔWID) of bleached teeth after sodium ascorbate application

decreases

Not recorded as a finding: no outcome node exists for post-bleaching tooth colour change

Application of 10% SA after in-office bleaching successfully reduced the penetration of HP into the pulp chamber; however, it decreased color change.

PMID:38133477 · one of two readings recorded this

microtensile bond strength (µTBS) to resin-enamel interface

decreases

However, significantly lower µTBS values (p < 0.00001) were obtained in the SA group than in the control and NSA groups (Table 3).

PMID:38133477 · one of two readings recorded this

microtensile bond strength (µTBS) to the resin-enamel interface after sodium ascorbate application post-bleaching

increases

Not recorded as a finding: no outcome node exists for dental resin-enamel microtensile bond strength

SA application significantly improved the µTBS values and reduced the HP concentrations within the pulp chambers (p < 0.0001).

PMID:38133477 · one of two readings recorded this

tooth colour change (ΔEab, ΔE00, ΔWID)

decreases

However, significant and lower color changes (p > 0.07) for all measurements (ΔEab, ΔE00, and ΔWiD) were observed for the SA group (Table 2).

PMID:38133477 · one of two readings recorded this

cerebral cortical temperature, implanted frontal cortex combination sensor

decreases, 39.2 [0.1]°C, restored from septic hyperthermia

Not recorded as a finding: CAT:outcome/core-body-temperature requires a rectal, oesophageal or ingestible telemetric CORE-site probe; this study measured cerebral cortex temperature via an implanted frontal cortex sensor, a different site — endpoint_near_miss, not a match

Sodium ascorbate restored cerebral perfusion (703 [121] units], oxygenation (30 [2] mm Hg), temperature (39.2 [0.1]°C) (all PTreatment<0.05), and the behavioural state to normal.

PMID:38960833 · one of two readings recorded this

cerebral cortical tissue oxygenation, oxygen-sensing probe

increases, (30 [2] mm Hg)

Not recorded as a finding: no outcome node exists for cerebral tissue oxygenation

Sodium ascorbate restored cerebral perfusion (703 [121] units], oxygenation (30 [2] mm Hg), temperature (39.2 [0.1]°C) (all PTreatment<0.05), and the behavioural state to normal.

PMID:38960833 · one of two readings recorded this

cerebral cortical tissue perfusion and oxygenation, implanted frontal cortex probe

increases, perfusion 703 [121] units; oxygenation 30 [2] mm Hg

Not recorded as a finding: no outcome node exists for cerebral cortical tissue perfusion or brain tissue oxygenation

Sodium ascorbate restored cerebral perfusion (703 [121] units], oxygenation (30 [2] mm Hg), temperature (39.2 [0.1]°C) (all PTreatment<0.05), and the behavioural state to normal.

PMID:38960833 · one of two readings recorded this

cerebral cortical tissue perfusion, combination sensor in frontal cerebral cortex

increases, (703 [121] units)

Not recorded as a finding: no outcome node exists for cerebral tissue perfusion

Sodium ascorbate restored cerebral perfusion (703 [121] units], oxygenation (30 [2] mm Hg), temperature (39.2 [0.1]°C) (all PTreatment<0.05), and the behavioural state to normal.

PMID:38960833 · one of two readings recorded this

cerebral cortical tissue perfusion, oxygenation and temperature, and plasma interleukin-6, VEGF-A and ascorbate concentrations in ovine Gram-negative sepsis

increases, cerebral perfusion 703 [121] units, oxygenation 30 [2] mmHg, temperature 39.2 [0.1]°C

Not recorded as a finding: this platform holds no node for the endpoint

Sodium ascorbate restored cerebral perfusion (703 [121] units], oxygenation (30 [2] mm Hg), temperature (39.2 [0.1]°C) (all PTreatment<0.05), and the behavioural state to normal.

PMID:38960833 · one of two readings recorded this

cerebral cortical tissue temperature, combination sensor in frontal cerebral cortex

decreases, (39.2 [0.1]°C, restored from a sepsis-induced hyperthermia of 40.8 [0.1]°C)

Not recorded as a finding: the core-body-temperature node requires a rectal, oesophageal, or ingestible telemetric-pill site; this study measured temperature with an intracranial frontal-cortex tissue probe, a different site the node does not cover (endpoint_near_miss)

Sodium ascorbate restored cerebral perfusion (703 [121] units], oxygenation (30 [2] mm Hg), temperature (39.2 [0.1]°C) (all PTreatment<0.05), and the behavioural state to normal.

PMID:38960833 · one of two readings recorded this

cerebral tissue perfusion, oxygenation and temperature

increases, perfusion 703 [121] units, oxygenation 30 [2] mmHg, temperature 39.2 [0.1]°C, n = 12

Sodium ascorbate restored cerebral perfusion (703 [121] units], oxygenation (30 [2] mm Hg), temperature (39.2 [0.1]°C) (all PTreatment<0.05), and the behavioural state to normal.

PMID:38960833 · one of two readings recorded this

plasma interleukin-6 and VEGF-A

decreases

Sodium ascorbate slightly reduced the sepsis-induced increase in interleukin-6, returned VEGF-A to normal (both PGroupxTime<0.01), and increased plasma ascorbate (20 000 [300] μM; PGroup<0.001).

PMID:38960833 · one of two readings recorded this

plasma VEGF-A concentration

Not recorded as a finding: no outcome node exists for VEGF-A

Sodium ascorbate slightly reduced the sepsis-induced increase in interleukin-6, returned VEGF-A to normal (both PGroupxTime<0.01), and increased plasma ascorbate (20 000 [300] μM; PGroup<0.001).

PMID:38960833 · both readings recorded this

sickness behaviour / behavioural state (malaise, lethargy) in septic sheep

decreases

Not recorded as a finding: no outcome node exists for animal sickness-behaviour severity

Sodium ascorbate restored cerebral perfusion (703 [121] units], oxygenation (30 [2] mm Hg), temperature (39.2 [0.1]°C) (all PTreatment<0.05), and the behavioural state to normal.

PMID:38960833 · one of two readings recorded this

biomass and total lipid content of Phaeodactylum tricornutum microalgae following sodium ascorbate antioxidant supplementation

increases, biomass +10%, total lipids +40%

Not recorded as a finding: this platform holds no node for the endpoint

SE treatment increased biomass by 10 % and total lipids by 40 %, especially C16:0 and C16:1 fatty acids.

PMID:40527426 · one of two readings recorded this

biomass and total lipid content

increases, biomass +10%, total lipids +40%

SE treatment increased biomass by 10 % and total lipids by 40 %, especially C16:0 and C16:1 fatty acids.

PMID:40527426 · one of two readings recorded this

cellular ascorbate (vitamin C) content of Phaeodactylum tricornutum

increases

Not recorded as a finding: no mechanism predicate captures raising an endogenous metabolite's concentration (depletes only covers lowering), and no outcome node exists for microalgal ascorbate content

Mechanistically, SE triggered chloroplast ROS accumulation and enhanced antioxidant defenses (higher VC levels and APX/CAT/SOD activities).

PMID:40527426 · one of two readings recorded this

microalgal biomass and total lipid content of Phaeodactylum tricornutum

increases, biomass +10%; total lipids +40%

Not recorded as a finding: no outcome node exists for microalgal biofuel biomass or lipid yield

SE treatment increased biomass by 10 % and total lipids by 40 %, especially C16:0 and C16:1 fatty acids.

PMID:40527426 · one of two readings recorded this

polyunsaturated fatty acid (PUFA) content

decreases

This response reduced PUFAs but increased overall lipid yield.

PMID:40527426 · one of two readings recorded this

cerebral tissue oxygenation and sickness behaviour

increases, 19.9 ± 4.7 to 31.2 ± 1.6 mmHg, p = 0.1

This clinical recovery paralleled normalization of cerebral tissue pO₂ (from 19.9 ± 4.7 mmHg at 23-h to 31.2 ± 1.6 mmHg at 31-h; baseline 35.9 ± 1.6 mmHg, P = 0.10; Fig. 6a–b).

PMID:41457243 · one of two readings recorded this

norepinephrine dose required to maintain MAP ~70 mmHg

decreases, p = 0.007, n = 8

In contrast, 3.0 g/kg sodium ascorbate rapidly reduced norepinephrine requirements to 0.2 ± 0.1 µg/kg/min at 31-h (Ptime*treatment = 0.007), with complete weaning off norepinephrine in 4 of 8 animals.

PMID:41457243 · one of two readings recorded this

norepinephrine (vasopressor) dose required to maintain mean arterial pressure in ovine Gram-negative sepsis

decreases, reduced to 0.2 ± 0.1 µg/kg/min at 31-h with complete weaning in 4 of 8 animals, vs progressive escalation in vehicle and lower-dose groups, p = 0.007, n = 8

Not recorded as a finding: CAT:outcome/time-to-vasopressor-discontinuation requires elapsed time to a stated washout (48 consecutive hours in the trials that defined it); this study reports a titrated infusion dose at a fixed timepoint under an actively controlled MAP target, not a discontinuation time with that washout, so the instrument does not match the node

In contrast, 3.0 g/kg sodium ascorbate rapidly reduced norepinephrine requirements to 0.2 ± 0.1 µg/kg/min at 31-h (Ptime*treatment = 0.007), with complete weaning off norepinephrine in 4 of 8 animals.

PMID:41457243 · one of two readings recorded this

plasma creatinine

decreases

In contrast, all three doses significantly attenuated the rise in plasma creatinine, with levels returning to or below baseline from 1.5 h of treatment (Ptime*treatment < 0.0001, Fig. 3a–b).

PMID:41457243 · one of two readings recorded this

renal medullary tissue oxygen tension

increases, p = 0.006

The highest dose (3.0 g/kg) rapidly reversed renal medullary hypoxia to baseline values, with this effect being sustained throughout the experiment (from 25.2 ± 0.002 at 23-h to 43.4 ± 0.8 mmHg at 31-h, P = 0.006, Fig. 2e, g).

PMID:41457243 · one of two readings recorded this

renal medullary tissue oxygenation and urine flow rate

increases, renal medullary oxygenation 25.2 ± 3.3 to 43.4 ± 4.5 mmHg; urine flow 0.5 ± 0.2 to 6.9 ± 2.4 ml/kg/h

Not recorded as a finding: no outcome node exists for renal medullary oxygenation or urine flow in septic sheep; the two measures share one sentence with distinct p-values so neither is paired here

The improvements in renal medullary oxygenation (25.2 ± 3.3 to 43.4 ± 4.5 mmHg, P = 0.04) and urine flow (from 0.5 ± 0.2 to 6.9 ± 2.4 ml/kg/h, P < 0.0001) were dose-dependent.

PMID:41457243 · one of two readings recorded this

renal medullary tissue oxygenation, oxygen-sensing probe

increases, (25.2 ± 3.3 to 43.4 ± 4.5 mmHg, P = 0.04), p = 0.04

Not recorded as a finding: no outcome node exists for renal medullary tissue oxygenation

The improvements in renal medullary oxygenation (25.2 ± 3.3 to 43.4 ± 4.5 mmHg, P = 0.04) and urine flow (from 0.5 ± 0.2 to 6.9 ± 2.4 ml/kg/h, P < 0.0001) were dose-dependent.

PMID:41457243 · one of two readings recorded this

urine flow rate, ml/kg/h

increases, (from 0.5 ± 0.2 to 6.9 ± 2.4 ml/kg/h, P < 0.0001)

Not recorded as a finding: no outcome node exists for urine output/flow rate

The improvements in renal medullary oxygenation (25.2 ± 3.3 to 43.4 ± 4.5 mmHg, P = 0.04) and urine flow (from 0.5 ± 0.2 to 6.9 ± 2.4 ml/kg/h, P < 0.0001) were dose-dependent.

PMID:41457243 · one of two readings recorded this

urine output

increases, 0.5 ± 0.2 to 6.9 ± 0.8 mL/kg/h

Sodium ascorbate caused a large dose-related increase in urine flow (from 0.5 ± 0.2 at 23-h to 6.9 ± 0.8 ml/kg/h at 31-h in 3.0 g/kg, Ptime*treatment < 0.0001, Fig. 3e, Table 2).

PMID:41457243 · one of two readings recorded this

vasopressor (norepinephrine) requirement to maintain mean arterial pressure

no effect

Not recorded as a finding: no outcome node exists for vasopressor dose/requirement itself, distinct from the MAP node used for the 3.0 g/kg claim; recorded here for the 1.0 and 2.0 g/kg doses, which showed no effect

Lower doses of sodium ascorbate (1.0 and 2.0 g/kg) had no significant effect on vasopressor requirements.

PMID:41457243 · one of two readings recorded this

28-day mortality / death or persistent organ dysfunction (ascorbic acid RCTs, narrated)

increases, unadjusted risk ratio, 1.21; 95% CI, 1.04 to 1.40, p = 0.01, n = 872

There was an increase in the primary outcome of death or persistent organ dysfunction at day 28 in the ascorbic acid group (unadjusted risk ratio, 1.21; 95%CI, 1.04 to 1.40; P = 0.01).

PMID:41485064 · one of two readings recorded this

hospital mortality (single-centre retrospective ascorbic acid + hydrocortisone + thiamine protocol, narrated)

decreases, 8.5% (4/47) vs 40.4% (19/47), n = 94

Hospital mortality (the primary outcome) was 8.5% (4/47) in the treatment group compared to 40.4% (19/47) in the control group (P < 0.001).

PMID:41485064 · one of two readings recorded this

vasopressor requirement and urine output, Phase I sodium ascorbate trial (narrated)

increases, n = 30

Subsequently, a Phase I, double-blind, placebo-controlled trial of IV sodium ascorbate (60 g) in 30 patients with septic shock demonstrated that the intervention was safe and feasible, with early signs of benefit, including increased urine output and reduced vasopressor requirements.

PMID:41485064 · one of two readings recorded this

Clostridium botulinum toxin formation in vacuum-packaged wieners

no effect

Not recorded as a finding: the intervention held more than the compound

Sodium ascorbate at levels of 105 and 655 mug/g of product did not decrease the effectiveness of the sodium nitrite inhibition, nor did sodium ascorbate potentiate it.

PMID:4596392 · one of two readings recorded this

Clostridium botulinum toxin formation in wieners

no effect

Sodium ascorbate at levels of 105 and 655 mug/g of product did not decrease the effectiveness of the sodium nitrite inhibition, nor did sodium ascorbate potentiate it.

PMID:4596392 · one of two readings recorded this

toxin formation by Clostridium botulinum in vacuum-packaged wieners, and the effectiveness of sodium nitrite's inhibition of that toxin formation

no effect

Not recorded as a finding: this platform holds no node for the endpoint

Sodium ascorbate at levels of 105 and 655 mug/g of product did not decrease the effectiveness of the sodium nitrite inhibition, nor did sodium ascorbate potentiate it.

PMID:4596392 · one of two readings recorded this

toxin formation by Clostridium botulinum in vacuum-packaged wieners, assessed for inhibition by sodium nitrite with or without sodium ascorbate

no effect

Not recorded as a finding: this platform holds no node for the endpoint

Sodium ascorbate at levels of 105 and 655 mug/g of product did not decrease the effectiveness of the sodium nitrite inhibition, nor did sodium ascorbate potentiate it.

PMID:4596392 · one of two readings recorded this

calcium phosphate-containing amorphous precipitate in urine

increases

This precipitate was observed in the present experiment in the rats administered the high dose of sodium saccharin or the higher doses of sodium ascorbate

PMID:7586194 · one of two readings recorded this

precipitate formation and urothelial proliferation

decreases

Formation of this precipitate and induction of urothelial proliferation were inhibited by co-administration of NH4Cl, but somewhat higher doses of ammonium chloride were required for doses of sodium ascorbate compared to sodium saccharin

PMID:7586194 · one of two readings recorded this

urinary tract effects (urothelial proliferation)

no effect

The lowest dose, 0.91%, was without effect on the urinary tract

PMID:7586194 · one of two readings recorded this

urothelial hyperplasia and labeling index in the male rat urinary bladder

increases

Not recorded as a finding: this platform holds no node for the endpoint

These results demonstrate that sodium ascorbate administered through the neonatal time period of the male rat produces urothelial hyperplasia in the dose responsive manner, with a no-effect level of 0.91% of the diet.

PMID:7586194 · one of two readings recorded this

urothelial hyperplasia and labeling index

decreases

Sodium saccharin administered as 5% of the diet produced urothelial hyperplasia and increased labeling index, and this was inhibited by co-administration with 1.23% NH4Cl

PMID:7586194 · one of two readings recorded this

urothelial hyperplasia and labeling index

increases

Sodium saccharin administered as 5% of the diet produced urothelial hyperplasia and increased labeling index, and this was inhibited by co-administration with 1.23% NH4Cl

PMID:7586194 · one of two readings recorded this

urothelial proliferative response

no effect

A slight effect (not statistically significant) was observed at a dose of 2.73%, and a significant proliferative response was detected at 4.56 and 6.84%

PMID:7586194 · one of two readings recorded this

urothelial proliferative response

increases

A slight effect (not statistically significant) was observed at a dose of 2.73%, and a significant proliferative response was detected at 4.56 and 6.84%

PMID:7586194 · one of two readings recorded this

urothelial proliferative response

increases

A slight effect (not statistically significant) was observed at a dose of 2.73%, and a significant proliferative response was detected at 4.56 and 6.84%

PMID:7586194 · one of two readings recorded this

cell loss

no effect

Significant cell loss was observed in Molt-4, but not in lymphocyte and fibroblast cultures, after 4 h of incubation in 50 microM of sodium ascorbate, a concentration similar to the plasma level of ascorbic acid in humans

PMID:9202729 · one of two readings recorded this

cell loss

increases

Significant cell loss was observed in Molt-4, but not in lymphocyte and fibroblast cultures, after 4 h of incubation in 50 microM of sodium ascorbate, a concentration similar to the plasma level of ascorbic acid in humans

PMID:9202729 · one of two readings recorded this

DNA single-strand breaks in human lymphocytes, fibroblasts and Molt-4 cells, alkaline microgel electrophoresis

increases

Not recorded as a finding: this platform holds no node for the endpoint

Incubation of human lymphocytes, neonatal fibroblasts, and Molt-4 cells (T-cell leukemia cell line) with sodium ascorbate for 1 h resulted in a concentration-dependent increase in DNA single-strand breaks as assayed by an alkaline microgel electrophoresis technique.

PMID:9202729 · one of two readings recorded this

DNA single-strand breaks in human lymphocytes, fibroblasts and Molt-4 cells by alkaline microgel electrophoresis

increases

Not recorded as a finding: this platform holds no node for the endpoint

Incubation of human lymphocytes, neonatal fibroblasts, and Molt-4 cells (T-cell leukemia cell line) with sodium ascorbate for 1 h resulted in a concentration-dependent increase in DNA single-strand breaks as assayed by an alkaline microgel electrophoresis technique.

PMID:9202729 · one of two readings recorded this

DNA single-strand breaks, sensitivity of fibroblasts and Molt-4 cells relative to lymphocytes

increases

Fibroblasts and Molt-4 cells were significantly more sensitive than lymphocytes to the induction of DNA single-strand breaks by 25, 50, and 100 microM concentrations of sodium ascorbate

PMID:9202729 · one of two readings recorded this

DNA single-strand breaks

increases

Incubation of human lymphocytes, neonatal fibroblasts, and Molt-4 cells (T-cell leukemia cell line) with sodium ascorbate for 1 h resulted in a concentration-dependent increase in DNA single-strand breaks as assayed by an alkaline microgel electrophoresis technique

PMID:9202729 · one of two readings recorded this

cytotoxic activity of sodium ascorbate and dopamine mixed

decreases

When these two compounds were mixed together before adding to HSC-4 cells, both of their cytotoxic activities were diminished

PMID:9870554 · one of two readings recorded this

cytotoxicity of sodium ascorbate and dopamine

decreases

Both of these two compounds dose-dependently reduced the viable cell number of human oral squamous carcinoma HSC-4 cells, and their cytotoxic activity was significantly reduced by catalase

PMID:9870554 · one of two readings recorded this

dopamine radical ESR signal

decreases

Addition of increasing concentrations of sodium ascorbate completely scavenged the dopamine radical and replaced the latter with its own radical

PMID:9870554 · one of two readings recorded this

dopamine radical intensity by ESR, methionine oxidation, hydrogen peroxide generation and viable cell number of HSC-4 cells

decreases

Not recorded as a finding: this platform holds no node for the endpoint

Addition of increasing concentrations of sodium ascorbate completely scavenged the dopamine radical and replaced the latter with its own radical.

PMID:9870554 · one of two readings recorded this

methionine oxidation and hydrogen peroxide generation in culture medium

increases

These two compounds stimulated the methionine oxidation and hydrogen peroxide generation in culture medium, but in combination, their stimulation activities were weakened

PMID:9870554 · one of two readings recorded this

methionine oxidation and hydrogen peroxide generation in culture medium

decreases

These two compounds stimulated the methionine oxidation and hydrogen peroxide generation in culture medium, but in combination, their stimulation activities were weakened

PMID:9870554 · one of two readings recorded this

sodium ascorbate radical intensity

decreases

Similarly, dopamine slightly, but significantly reduced the radical intensity of sodium ascorbate

PMID:9870554 · one of two readings recorded this

viable HSC-4 cell number

decreases

Both of these two compounds dose-dependently reduced the viable cell number of human oral squamous carcinoma HSC-4 cells, and their cytotoxic activity was significantly reduced by catalase

PMID:9870554 · one of two readings recorded this