Compound
neurotensin
A biologically active tridecapeptide isolated from the hypothalamus. It has been shown to induce hypotension in the rat, to stimulate contraction of guinea pig ileum and rat uterus, and to cause relaxation of rat duodenum. There is also evidence that it acts as both a peripheral and a central nervous system neurotransmitter.
Structure
No three-dimensional record for this entry.
- Class
- Organic compound, cation
- Formula
- C78H122N21O20
- Mass
- 1673.961 g/mol
- Charge
- +1
- InChIKey
- PCJGZPGTCUMMOT-ISULXFBGSA-O
- SMILES
- CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCC[NH3+])NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)[O-])NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)[O-]
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
4 entities
4 entities reached.
0 reported hops4 assembled from the scaffold
What the reference databases state
Statements
6 statements
6 statements · 2 reference databases · Subject: neurotensin · Sources: Human-GEM, Rhea
- neurotensin is a substrate of ACEProteinRhea RHEA:71475Inferred only
- neurotensin is a substrate of ACE2ProteinRhea RHEA:63540Inferred only
- neurotensin is a substrate of MMEProteinRhea RHEA:71475Inferred only
- neurotensin is a substrate of MMEProteinRhea RHEA:71479Inferred only
- neurotensin is a substrate of NLNProteinHuman-GEM MAR02698Inferred only
- neurotensin is a substrate of NLNProteinHuman-GEM MAR09468Inferred only
Reactions
5 reactions
water+neurotensinMAM02571m+MAM02572m
Catalysed by NLN
Reaction pageReversibleBalancedEC 3.4.24.16mitochondrial matrix
Human-GEM MAR02698CC BY 4.0Reference data
water+neurotensinMAM02571c+MAM02572c
Catalysed by NLN
Reaction pageLeft to rightBalancedEC 3.4.24.16cytosol
Human-GEM MAR09468CC BY 4.0Reference data
neurotensin+waterneurotensin-(1-12)+L-leucine
Catalysed by ACE2
Reaction pageLeft to rightBalanced
Rhea RHEA:63540CC BY 4.0Reference data
neurotensin+waterneurotensin(1-11)+L-isoleucyl-L-leucine
Reaction pageLeft to rightBalanced
Rhea RHEA:71475CC BY 4.0Reference data
neurotensin+waterneurotensin(1-10)+L-tyrosyl-L-isoleucyl-L-leucine
Catalysed by MME
Reaction pageLeft to rightBalanced
Rhea RHEA:71479CC BY 4.0Reference data
Other names
6 names
Resolves to: neurotensin
- Also called
- L-Pyr-L-Leu-L-Tyr-L-Glu-L-Asn-L-Lys-L-Pro-L-Arg-L-Arg-L-Pro-L-Tyr-L-Ile-L-Leu(1+)L-pyroglutamyl-L-leucyl-L-tyrosyl-L-alpha-glutamyl-L-asparagyl-L-lysyl-L-prolyl-L-arginyl-L-arginyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine(1+)L-pyroglutamyl-L-leucyl-L-tyrosyl-L-α-glutamyl-L-asparagyl-L-lysyl-L-prolyl-L-arginyl-L-arginyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine(1+)Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu(1+)
- Systematic name
- 5-oxo-L-prolyl-L-leucyl-L-tyrosyl-5-oxidanidyl-5-oxidanylidene-L-norvalyl-L-asparaginyl-6-azaniumyl-L-norleucyl-L-prolyl-N(5)-[amino(iminio)methyl]-L-ornithyl-N(5)-[amino(iminio)methyl]-L-ornithyl-L-prolyl-L-tyrosyl-N-[(1S)-1-carboxylato-3-methylbutyl]-L-isoleucinamide5-oxo-L-prolyl-L-leucyl-L-tyrosyl-5-oxidanidyl-5-oxidanylidene-L-norvalyl-L-asparaginyl-6-azaniumyl-L-norleucyl-L-prolyl-N5-[amino(iminio)methyl]-L-ornithyl-N5-[amino(iminio)methyl]-L-ornithyl-L-prolyl-L-tyrosyl-N-[(1S)-1-carboxylato-3-methylbutyl]-L-isoleucinamide