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Produced a finding 1 paper PMID:16555951 cited by PMID:34417881 [mechanism]; about CHEBI:6650 by its own indexing 2026-10-12 Discarded — another reason, stated per paper 71 papers PMID:31235694 no claim extracted — subject_absent — DOSED: PGC-1α1-driven kynurenine metabolism and the malate-aspartate shuttle in mouse skeletal muscle; malic acid itself is never administered or measured as a discrete compound, only named as part of the shuttle pathway | Skeletal muscle PGC-1α1-driven kynurenine metabolism and the malate-aspartate shuttle in exercise-trained mice, and Kat inhibition with carbidopa; malate is named only as part of the shuttle's name and is never itself administered or measured pipeline:batch 2026-09-29 NCT00137436 design×1 — allocation NON_RANDOMIZED -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09 NCT00257010 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09 NCT00265798 design×1 — allocation NA -- not randomised Discarded — the wrong intervention 30 papers PMID:38506527 no claim extracted — subject_is_the_outcome pipeline:batch 2026-09-29 NCT03030599 intervention×1 — no declared intervention names malic acid clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09 NCT00326898 intervention×1 — no declared intervention names malic acid clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09 NCT00338884 intervention×1 — no declared intervention names malic acid clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09 Discarded — an endpoint this vocabulary does not hold 10 papers PMID:34954846 no claim extracted — no_outcome_node — measured: xerostomia/dry mouth symptom severity by DMQ, XI and VAS, and unstimulated/stimulated salivary flow rate | unstimulated and stimulated saliva flow rate, measured after a two-week course of treatment pipeline:batch 2026-09-19 PMID:38514904 claims extracted but the object named resolved to no node — recorded in candidate_nodes (ADR-0070) pipeline:batch 2026-09-29 PMID:22926481 no claim extracted — no_outcome_node — measured: dry mouth symptom score, Dry Mouth Questionnaire 0-to-4 rating; unstimulated and stimulated salivary flow rate by timed collection, mL/min | xerostomia symptom severity, Dry Mouth Questionnaire 0-to-4 rating scale; salivary flow rate by sialometry, mL/min pipeline:batch 2026-10-11 PMID:23124914 no claim extracted — no_outcome_node — measured: dry mouth symptom score, Dry Mouth Questionnaire; unstimulated and stimulated salivary flow rate | dry mouth symptom severity, dry mouth questionnaire (DMQ); salivary flow rate, unstimulated and stimulated Discarded — no extractable result 3 papers NCT01652001 declared_contrast×2 — no posted analysis compares a malic acid arm with a placebo/no-intervention arm and carries a p-value (Malic Acid 1%=EXPERIMENTAL+subject, Control=PLACEBO_COMPARATOR) clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09 PMID:35993419 no claim extracted — no_quantitative_result pipeline:batch 2026-10-12 PMID:37519180 claims extracted but the two passes did not agree pipeline:batch 2026-10-12 Not read yet 25 papers Back to malic acid
clinicaltrials.gov intr search: query.intr=malic acid
2026-10-09
NCT00330564 design×1 — allocation NON_RANDOMIZED -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00387426 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00388037 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00389974 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00392444 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00392496 design×1 — allocation NON_RANDOMIZED -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00398112 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00417885 design×1 — allocation NON_RANDOMIZED -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00425386 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00453310 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00459979 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00462982 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00463060 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00471276 design×1 — allocation NON_RANDOMIZED -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00474994 design×1 — allocation NON_RANDOMIZED -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00482911 design×1 — allocation NON_RANDOMIZED -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00499473 design×1 — allocation NON_RANDOMIZED -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00519896 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00520533 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00524316 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00526656 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00555620 design×1 — allocation NON_RANDOMIZED -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00555672 design×1 — allocation NON_RANDOMIZED -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00599924 design×1 — allocation NON_RANDOMIZED -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00606008 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00616122 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00656669 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00662025 design×1 — allocation NON_RANDOMIZED -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00672594 design×1 — allocation NON_RANDOMIZED -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00702884 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00716625 design×1 — studyType OBSERVATIONAL -- only INTERVENTIONAL is extracted clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00787787 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00793871 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00824538 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00843037 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00847015 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00849186 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00853372 design×1 — allocation NON_RANDOMIZED -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00859339 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00859456 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00864721 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00910039 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00912912 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT01118351 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT01258348 design×1 — allocation absent -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT01462695 design×1 — allocation NON_RANDOMIZED -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT01525550 design×1 — allocation absent -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT01811212 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT01812668 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT01822522 design×1 — allocation NON_RANDOMIZED -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT01935934 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT02243605 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT02315430 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT03914300 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT04079712 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT04514484 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT05542342 design×1 — allocation NA -- not randomised clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09 PMID:29925712 no claim extracted — cause not determined (one pass only) — measured: oral health-related quality of life, Oral Health Impact Profile-14 (Spanish version) total score; dry mouth sensation, VAS; salivary flow rate, mL/min pipeline:batch 2026-10-11 PMID:21561434 no claim extracted — cause not determined pipeline:batch 2026-10-12 PMID:37182630 no claim extracted — subject_absent — DOSED: poly(beta-L-malic acid) (PMLA), glucose-terminated polymer, not L-malic acid monomers, abstract | poly(beta-L-malic acid) (PMLA) produced by Aureobasidium melanogenum ipe-1, glucose-terminated polymer, abstract pipeline:batch 2026-10-12 PMID:38517568 no claim extracted — subject_absent — DOSED: poly(malic acid)-budesonide (PMAB) nanoconjugates in nano-embedded microparticles, abstract | poly(malic acid)-budesonide (PMAB) nanoconjugates embedded in spray-dried microparticles, abstract pipeline:batch 2026-10-12 PMID:39428822 no claim extracted — subject_absent — DOSED: poly(beta-L-malic acid) (PMLA) enzyme/pH-sensitive nanoparticles carrying doxorubicin, abstract | enzyme/pH-sensitive nanoparticles (EP-NPs) based on poly(beta-L-malic acid) carrying doxorubicin, abstract pipeline:batch 2026-10-12 PMID:10783895 no claim extracted — subject_absent — DOSED: paper is about mitochondrial superoxide and hyperglycaemic damage; malic acid is not mentioned in the abstract | no malic acid in the abstract; paper is about mitochondrial superoxide and hyperglycaemic damage, Abstract pipeline:batch 2026-10-12 PMID:34390209 no claim extracted — cause not determined (one pass only) — measured: engineered yeast malic acid titer, g/L from xylose in fed-batch culture pipeline:batch 2026-10-12 PMID:36370855 no claim extracted — subject_absent — DOSED: poly(beta-L-malic acid) (PMLA) produced by fermentation; malic acid monomer not dosed or measured | poly(beta-L-malic acid), a microbial product; not given to any subject, Abstract pipeline:batch 2026-10-12 PMID:36608859 no claim extracted — cause not determined (one pass only) — measured: engineered yeast l-malic acid titer, g/L in 3-L bioreactor pipeline:batch 2026-10-12 PMID:36812909 no claim extracted — cause not determined (one pass only) — measured: engineered fungal l-malic acid titer, g/L in 5 L fed-batch pipeline:batch 2026-10-12 NCT00372567
intervention×1 — no declared intervention names malic acid
clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00373113 intervention×1 — no declared intervention names malic acid clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00393939 intervention×1 — no declared intervention names malic acid clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00428597 intervention×1 — no declared intervention names malic acid clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00453154 intervention×1 — no declared intervention names malic acid clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00693992 intervention×1 — no declared intervention names malic acid clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT00698815 intervention×1 — no declared intervention names malic acid clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT01185366 intervention×1 — no declared intervention names malic acid clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT01391962 intervention×1 — no declared intervention names malic acid clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT01708954 intervention×1 — no declared intervention names malic acid clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT01944774 intervention×1 — no declared intervention names malic acid clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT03367741 intervention×1 — no declared intervention names malic acid clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT03375320 intervention×1 — no declared intervention names malic acid clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT03468985 intervention×1 — no declared intervention names malic acid clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT03953079 intervention×1 — no declared intervention names malic acid clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09
NCT04472650 intervention×1 — no declared intervention names malic acid clinicaltrials.gov intr search: query.intr=malic acid 2026-10-09 PMID:23377327 no claim extracted — combination_exposure pipeline:batch 2026-10-11 PMID:38487986 no claim extracted — combination_exposure pipeline:batch 2026-10-11 PMID:8587088 no claim extracted — combination_exposure pipeline:batch 2026-10-11 PMID:38268424 no claim extracted — subject_is_the_outcome pipeline:batch 2026-10-12 PMID:38407053 no claim extracted — subject_is_the_outcome pipeline:batch 2026-10-12 PMID:38777233 no claim extracted — subject_is_the_outcome pipeline:batch 2026-10-12 PMID:39444231 no claim extracted — subject_is_the_outcome pipeline:batch 2026-10-12 PMID:40147662 no claim extracted — subject_is_the_outcome pipeline:batch 2026-10-12 PMID:15262965 no claim extracted — reagent_not_exposure pipeline:batch 2026-10-12 PMID:17447126 no claim extracted — reagent_not_exposure pipeline:batch 2026-10-12 pipeline:batch 2026-10-11
PMID:23294350 no claim extracted — no_outcome_node — measured: xerostomia symptom score, Xerostomia Inventory; unstimulated and stimulated salivary flow rate | xerostomia symptom severity, Xerostomia Inventory (XI) score; salivary flow rate, unstimulated and stimulated pipeline:batch 2026-10-11 PMID:30818311 no claim extracted — no_outcome_node — measured: dry mouth symptom score, Dry Mouth Questionnaire 0-4 rating; unstimulated salivary flow rate, mL/min | xerostomia symptom severity on the Dry Mouth Questionnaire (DMQ); unstimulated salivary flow rate in mL/min pipeline:batch 2026-10-11 PMID:35913424 no claim extracted — no_outcome_node — measured: xerostomia symptom score, Summated Xerostomia Inventory-Dutch Version; unstimulated salivary flow rate | xerostomia symptom severity, Summated Xerostomia Inventory-Dutch Version (SXI-D); unstimulated salivary flow rate pipeline:batch 2026-10-11 PMID:40381742 no claim extracted — no_outcome_node — measured: airway inflammation in HDM-induced asthma mouse model | airway inflammation in HDM-induced asthma, mouse (readout not stated in abstract) pipeline:batch 2026-10-12 PMID:41240543 no claim extracted — no_outcome_node — measured: intestinal epithelial fucosylation / mucus barrier integrity in DSS-induced colitis in mice | intestinal epithelial fucosylation and mucus barrier integrity in DSS colitis, mouse (readout not stated in abstract) pipeline:batch 2026-10-12 PMID:41713814 no claim extracted — no_outcome_node — measured: PGE2-induced mechanical hyperalgesia (antinociceptive effect) in mice | antinociception in PGE2-induced hyperalgesia, mouse (instrument not stated in abstract) pipeline:batch 2026-10-12 query not recorded 2026-09-01
PMID:2339872 cited by PMID:18214471 [cited]; about CHEBI:6650 by its own indexing 2026-09-29 PMID:18162271 cited by PMID:34281289 [cited]; about CHEBI:6650 by its own indexing 2026-09-29 PMID:21908472 cited by PMID:34281289 [cited]; about CHEBI:6650 by its own indexing 2026-09-29 PMID:31639642 cited by PMID:34281289 [cited]; about CHEBI:6650 by its own indexing 2026-09-29 PMID:7681395 cited by PMID:34281289 [cited]; about CHEBI:6650 by its own indexing 2026-09-29 PMID:11526017 cited by PMID:36646426 [cited]; about CHEBI:6650 by its own indexing 2026-09-29 PMID:12802505 cited by PMID:36646426 [cited]; about CHEBI:6650 by its own indexing 2026-09-29 PMID:1293882 cited by PMID:36646426 [cited]; about CHEBI:6650 by its own indexing 2026-09-29 PMID:18344340 cited by PMID:36646426 [cited]; about CHEBI:6650 by its own indexing 2026-09-29 PMID:24045196 cited by PMID:36646426 [cited]; about CHEBI:6650 by its own indexing 2026-09-29 PMID:33474701 cited by PMID:36646426 [cited]; about CHEBI:6650 by its own indexing 2026-09-29 PMID:8750236 cited by PMID:36646426 [cited]; about CHEBI:6650 by its own indexing 2026-09-29 PMID:8987728 cited by PMID:36646426 [cited]; about CHEBI:6650 by its own indexing 2026-09-29 PMID:9062925 cited by PMID:36646426 [cited]; about CHEBI:6650 by its own indexing 2026-09-29 PMID:15208291 cited by PMID:37155582 [cited]; about CHEBI:6650 by its own indexing 2026-09-29 PMID:32198407 cited by PMID:39025852 [cited]; about CHEBI:6650 by its own indexing 2026-09-29 PMID:27002734 cited by PMID:40565253 [cited]; about CHEBI:6650 by its own indexing 2026-09-29 PMID:27989324 cited by PMID:41828579 [cited]; about CHEBI:6650 by its own indexing 2026-09-29 PMID:14625276 cited by PMID:21151885 [mechanism]; about CHEBI:6650 by its own indexing 2026-10-13