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PapersPMID:42928353

Chlorella for health: evidence from a GRADE-assessed systematic review and dose-response meta-analysis.

Systematic reviews2026The record ↗

findings
2
compound
1
endpoints
2
  1. Finding, moderate evidencelowersSerum leptin
  2. Finding, moderate evidencelowersC-reactive protein concentration
Study, every finding
meta-analysis
  • “Chlorella supplementation was associated with a significant reduction in leptin levels (WMD = −0.71 ng/mL; 95% CI: −1.27, −0.15; P = 0.012; I2 = 0.0%, P = 0.538) (Supplementary Fig. 8).”
    Effect
    −0.71 mean difference, 95% CI −1.27 to −0.15
    Interests
    An author is affiliated with a producer
    Population
    Obese adults in controlled trials of chlorella supplementation (pooled leptin estimate from two trials: Karbalamahdi 2019, obese women; Delfan 2024, obese men)
  • “Chlorella supplementation significantly reduced hs-CRP levels (WMD: −421.66 ng/mL; 95% CI: −758.52 to −84.81; P = 0.014; I2 = 87.1%, P < 0.001) (Supplementary Fig. 4).”
    Effect
    −421.66 mean difference, 95% CI −758.52 to −84.81
    Interests
    An author is affiliated with a producer
    Population
    Adults in controlled trials of chlorella supplementation (pooled estimate for hs-CRP from two trials: primary dysmenorrhea, and overweight or obese men; Haidari 2018 and Tofighi 2024)

Study record

Design
meta-analysis
Species
human
Population
Adults in 33 controlled trials of Chlorella supplementation (healthy, overweight/obese and chronic disease populations)
Participants
not reported
Comparator
placebo
Duration
not reported
Endpoints measured
42