Papers/PMID:42646594
Sertraline as an Antidepressant and Inflammatory Cytokines in Depressive Disorders: A Systematic Review and Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials.
Medical sciences (Basel, Switzerland)2026The record
2 findings · 1 compound · 2 endpoints · 2 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
2 findings
sertraline — no detected effect on tumour necrosis factor alpha concentration
LikelyGrade B, Likely. Human evidence with one recorded weakness, or capped at B by its design or by unread numbers.FindingNull result“Overall, the pooled results suggest that sertraline did not significantly alter circulating levels of IL-6, IL-10, or TNF-α across the included studies.”
Quoted verbatim from Sertraline as an Antidepressant and Inflammatory Cytokines in Depressive Disorders: A Systematic Review and Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials.. - Study
- meta-analysis
- Population
- adults treated with sertraline for depressive disorders, pooled across trials with mixed comorbidities including coronary heart disease and chronic kidney disease
Sertraline as an Antidepressant and Inflammatory Cytokines in Depressive Disorders: A Systematic Review and Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials.2026PMID:42646594Permalink
sertraline — no detected effect on interleukin-6 concentration
LikelyGrade B, Likely. Human evidence with one recorded weakness, or capped at B by its design or by unread numbers.FindingNull result“Overall, the pooled results suggest that sertraline did not significantly alter circulating levels of IL-6, IL-10, or TNF-α across the included studies.”
Quoted verbatim from Sertraline as an Antidepressant and Inflammatory Cytokines in Depressive Disorders: A Systematic Review and Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials.. - Study
- meta-analysis
- Population
- adults treated with sertraline for depressive disorders, pooled across trials with mixed comorbidities including coronary heart disease and chronic kidney disease
Sertraline as an Antidepressant and Inflammatory Cytokines in Depressive Disorders: A Systematic Review and Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials.2026PMID:42646594Permalink