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PapersPMID:42420253

Beneficial effects of Chlorella species supplementation in the general population: a GRADE-assessed systematic review and dose-response meta-analysis.

Nutrition & diabetes2026The record ↗

findings
4
compound
1
endpoints
4
PMID:42420253
  1. Finding, moderate evidencelowersSerum leptin
  2. Finding, moderate evidencelowersBody mass index
  3. Finding, moderate evidencelowersBody mass
  4. Finding, moderate evidencelowersWaist-to-hip ratio
Study, every finding
meta-analysis

What moved

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  • Decreases serum leptin

    moderate

    “Chlorella supplementation significantly reduced leptin levels (WMD = −0.71 ng/ml; 95% CI: −1.27 to −0.16; p = 0.012; I² = 0.0%; p = 0.538).”
    Effect
    −0.71 mean difference, 95% CI −1.27 to −0.16
    Interests
    An author is affiliated with a producer
    Population
    Obese adults in controlled trials of chlorella (leptin pooled from two trials: Karbalamahdi 2019, women; Delfan 2024, men)
  • “Chlorella supplementation demonstrated statistically significant reductions in BF% (WMD = −0.73%; 95% CI: −1.18 to −0.29; p = 0.001; I² = 28.9%; p = 0.179), BMI (WMD = −0.30 kg/m2; 95% CI: −0.48 to −0.13; p = 0.001; I² = 21.3%; p = 0.186), weight (WMD = −1.28 kg; 95% CI: −2.00 to −0.56; p < 0.001; I² = 20.6%; p = 0.173), and WHR (WMD = −0.01%; 95% CI: −0.02 to −0.01; p < 0.001; I² = 0.0%; p = 0.859).”
    • Decreases body mass index

      moderate

      Effect
      −0.3 mean difference, 95% CI −0.48 to −0.13
      Interests
      An author is affiliated with a producer
      Population
      Adults without chronic disease (healthy weight, overweight or obese) in controlled trials of chlorella; in several trials both arms also did the same exercise programme
    • Decreases body mass

      moderate

      Effect
      −1.28 mean difference, 95% CI −2 to −0.56
      Interests
      An author is affiliated with a producer
      Population
      Adults without chronic disease (healthy weight, overweight or obese) in controlled trials of chlorella; in several trials both arms also did the same exercise programme
    • Decreases waist-to-hip ratio

      moderate

      Effect
      −0.01 mean difference, 95% CI −0.02 to −0.01
      Interests
      An author is affiliated with a producer
      Population
      Adults without chronic disease (overweight, obese or healthy weight) in controlled trials of chlorella; in several trials both arms also did the same exercise programme

Study record

Design
meta-analysis
Species
human
Population
Adults without underlying chronic disease (healthy weight, overweight or obese) in 24 controlled trials of Chlorella supplementation
Participants
815
Comparator
placebo
Duration
not reported
Endpoints measured
25