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PapersPMID:42050478

Effect of curcumin intervention on radiation-induced injury: a GRADE-based systematic review and meta-analysis.

BMC cancer2026The record ↗

findings
2
compound
1
endpoints
2
  1. Finding, moderate evidencelowersVisual analogue scale pain intensity
  2. Finding, moderate evidencelowersNumeric rating scale (NRS) pain intensity
Study, every finding
meta-analysis

What moved

How to read these marks →
  • “Accordingly, it has been shown that curcumin was associated with decreased NRS score (SMD: -7.56, 95% CI: -9.47, -5.65, P < 0.001; I2 = 0.0%, P = 0.515) and VAS score (SMD: -1.53, 95% CI: -2.52, -0.54, P = 0.002; I2 = 69.0%, P = 0.072) in patients with RII.”
    • Decreases visual analogue scale pain intensity

      moderatereplicated ×2

      Effect
      −1.53 standardised mean difference, 95% CI −2.52 to −0.54
      Population
      Adult cancer patients with radiation-induced injury during radiotherapy or radiochemotherapy; pain pooled from two trials using the visual analogue scale, oral or topical curcumin
    • Decreases numeric rating scale (NRS) pain intensity

      moderate

      Effect
      −7.56 standardised mean difference, 95% CI −9.47 to −5.65
      Population
      Adult cancer patients with radiation-induced injury during radiotherapy or radiochemotherapy; pain pooled from two trials using the numeric rating scale, oral or topical curcumin

Study record

Design
meta-analysis
Species
human
Population
adult cancer patients (18-80 years) undergoing radiotherapy or radiochemotherapy, with radiation-induced injury (RII); 17 RCTs, 1,307 patients
Participants
1,307
Comparator
placebo
Duration
not reported
Endpoints measured
25