PapersPMID:41828600
Acanthopanax senticosus Saponins Mitigate Left Ventricular Remodelling and Inhibit the Induction of MMP-2, MMP-9 in a Rat Model of Myocardial Infarction.
What moved
1 findingHow to read these marks →“Compared with the Model group, both ASS 50 and 100 mg/kg groups significantly reduced the content of TNF-α and IL-1β in the Model group increased significantly (p < 0.01).”
- Study
- animal · not in humans
- Duration
- 4 weeks
- Dose studied
- 50 mg/kg or 100 mg/kg once daily by intragastric gavage
- Population
- Male Wistar rats, 28 days after coronary artery (LAD) ligation to model myocardial infarction and left ventricular remodelling; serum TNF-α by ELISA kit; ASS 50 and 100 mg/kg groups against the untreated Model group
Study record
- Design
- animal study, in vivo
- Species
- animal
- Population
- Male Wistar rats with left anterior descending coronary artery ligation (myocardial infarction, ventricular remodelling)
- Participants
- 50
- Comparator
- not stated in the paper / placebo
- Duration
- 28 days
- Endpoints measured
- 35