Papers/PMID:41499173
Dapagliflozin Reduces Kidney Inflammation in Alport Syndrome by Inhibiting the Stimulator of IFN Genes Pathway in Renal Tubular Epithelial Cells.
Kidney3602026The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
dapagliflozin — inhibits STING1
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“Dapagliflozin effectively inhibited STING activation and suppressed inflammatory cytokines production in mutant TECs.”
Quoted verbatim from Dapagliflozin Reduces Kidney Inflammation in Alport Syndrome by Inhibiting the Stimulator of IFN Genes Pathway in Renal Tubular Epithelial Cells.. - Study
- in vitro · not in humans
- Population
- tubular epithelial cells from Col4a3-mutant Alport syndrome mice
Dapagliflozin Reduces Kidney Inflammation in Alport Syndrome by Inhibiting the Stimulator of IFN Genes Pathway in Renal Tubular Epithelial Cells.2026PMID:41499173Permalink