PapersPMID:41428718
The Effect of Vitex Agnus - Castus Plant on Some Markers of Oxidative Stress, Lipid Profile and Insulin Resistance in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind Controlled Clinical Trial Study.
- findings
- 3
- compound
- 1
- endpoints
- 3
- Study, every finding
- RCT · 3 months
- Dose studied, every finding
- 5.8 mg daily, orally, 12 weeks
What moved
How to read these marks →“Based on ANCOVA, values of TAC (p<0.001), GPx (p<0.05), GSH (p<0.05), TT (p<0.05), HDL (p<0.001), and menstrual frequency (p<0.05) were significantly increased after the intervention compared to the placebo group.”
- Population
- Women aged 18-45 years with PCOS (Rotterdam criteria); both arms continued metformin and a combined oral contraceptive; ANCOVA-adjusted post-intervention comparison
“Furthermore, values of TOS (p<0.001), OSI (p<0.001), MDA (p<0.001), FBS (p<0.001), HOMA-IR (p<0.05), ALT (0.05), mFG (0.001), and LDL (p<0.05) significantly decreased by the consumption of the Vitex compared to the placebo group.”
- Decreases fasting blood glucose
moderate
- Population
- Women aged 18-45 years with PCOS (Rotterdam criteria); both arms continued metformin and a combined oral contraceptive; independent t-test comparison at trial end
- Decreases HOMA-IR
moderate
- Population
- Women aged 18-45 years with PCOS (Rotterdam criteria); both arms continued metformin and a combined oral contraceptive; independent t-test comparison at trial end
Study record
- Design
- randomised controlled trial
- Species
- human
- Population
- Women with polycystic ovary syndrome (Rotterdam criteria)
- Participants
- 60
- Comparator
- placebo
- Duration
- 84 days
- Endpoints measured
- 24