Papers/PMID:41342306
Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD).
The Cochrane database of systematic reviews2025The record
2 findings · 1 compound · 2 endpoints · 2 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
2 findings
methylphenidate — no detected effect on health-related quality of life
PreliminaryGrade D, Preliminary. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Methylphenidate may improve teacher-rated general behaviour versus placebo (SMD -0.62, 95% CI -0.91 to -0.33; I² = 68%; 7 trials 792 participants; very low-certainty evidence), but may not affect quality of life (SMD 0.40, 95% CI -0.03 to 0.83; I² = 81%; 4 trials, 608 participants; very low-certainty evidence).”
Quoted verbatim from Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD).. - Study
- meta-analysis
- Participants
- 608
- Population
- children and adolescents with ADHD; secondary outcome (quality of life), instrument not named by the review
Effect 0.4 standardised mean difference, 95% CI -0.03 to 0.83
Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD).2025PMID:41342306Permalink
methylphenidate — no detected effect on serious adverse event incidence
PreliminaryGrade D, Preliminary. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Methylphenidate may not affect serious adverse events (risk ratio (RR) 0.80, 95% CI 0.39 to 1.67; I² = 0%; 26 trials, 3673 participants; very low-certainty evidence).”
Quoted verbatim from Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD).. - Study
- meta-analysis
- Participants
- 3,673
- Population
- children and adolescents with ADHD; primary outcome (serious adverse events)
Effect 0.8 risk ratio, 95% CI 0.39 to 1.67
Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD).2025PMID:41342306Permalink