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PapersPMID:40871607

Whey Protein Supplementation Combined with Exercise on Muscle Protein Synthesis and the AKT/mTOR Pathway in Healthy Adults: A Systematic Review and Meta-Analysis.

Nutrients2025The record ↗

  1. Finding, moderate evidenceraisesMuscle protein fractional synthetic rate

What moved

1 findingHow to read these marks →
  • “The findings demonstrated that the combination of exercise and whey protein supplementation resulted in a significant increase in myofibrillar FSR compared to exercise alone (Hedge’s g of 1.87; 95% CI: 0.99 to 2.76; p < 0.001).”
    Study
    meta-analysis
    Effect
    1.87 standardised mean difference, 95% CI 0.99 to 2.76
    Dose studied
    10 g to 60 g of whey protein per session, taken around a single exercise bout
    Population
    Healthy non-sedentary adults (371 participants across the 21 included trials, 338 men and 33 women, most with resistance-training experience), myofibrillar FSR measured 3 to 5 h after a single exercise bout; 10 trials pooled; the exercise bout was given to both arms

Study record

Design
meta-analysis
Species
human
Population
Healthy non-sedentary adults, mostly male, in 21 RCTs of whey protein (hydrolyzed, concentrated or isolated; form recorded per trial) combined with an acute exercise bout; muscle biopsy outcomes
Participants
371
Comparator
an active treatment / placebo
Duration
not reported
Endpoints measured
26
Declined
the paper never states the instrument the node requires