PapersPMID:39969338
Influence of phytosomal curcumin on anthropometric indices for nonalcoholic fatty liver disease: A meta-analysis.
- findings
- 4
- compound
- 1
- endpoints
- 4
- no difference found
- 1
curcumin- Study, every finding
- meta-analysis
- Dose studied, every finding
- phytosomal curcumin 250 to 1000 mg/day for 8 to 12 weeks across trials (one trial 800 mg), pooled
What moved
How to read these marks →- Decreases body mass index
moderatereplicated ×8
“The results unraveled that compared to placebo in nonalcoholic fatty liver disease, phytosomal curcumin resulted in significantly reduced BMI (MD = −0.72; 95% CI = −1.11 to −0.33; P =.0003) with significant heterogeneity among the studies (I2 = 69%, heterogeneity P =.006, Fig. 3) and body fat percent (MD = −2.04; 95% CI = −3.10 to −0.98; P =.0002) with low heterogeneity among the studies (I2 = 36%, heterogeneity P =.21, Fig. 4).”
- Effect
- −0.72 mean difference, 95% CI −1.11 to −0.33
- Population
- Adults with nonalcoholic fatty liver disease in randomised trials of phytosomal curcumin versus placebo; BMI pooled from 6 of 7 trials
“In comparison with placebo, phytosomal curcumin was associated with decreased weight (MD = −2.15; 95% CI = −3.78 to −0.53; P =.01; Fig. 5) and waist circumference (MD = −2.09; 95% CI = −4.05 to −0.12; P =.04; Fig. 6), but demonstrated no effect on hip circumference (MD = −0.06; 95% CI = −0.59 to 0.47; P =.83; Fig. 7) or waist/hip ratio (MD = 0; 95% CI = −0.01 to 0.01; P = 1; Fig. 8).”
- Decreases body mass
moderatereplicated ×3
- Effect
- −2.15 mean difference, 95% CI −3.78 to −0.53
- Population
- Adults with nonalcoholic fatty liver disease in randomised trials of phytosomal curcumin versus placebo; weight pooled from 4 of 7 trials
- Decreases waist circumference
moderate
- Effect
- −2.09 mean difference, 95% CI −4.05 to −0.12
- Population
- Adults with nonalcoholic fatty liver disease in randomised trials of phytosomal curcumin versus placebo; waist circumference pooled from 4 of 7 trials
What did not
- No detected effect on waist-to-hip ratio
moderatereplicated ×2
- Effect
- 0 mean difference, 95% CI −0.01 to 0.01
- Population
- Adults with nonalcoholic fatty liver disease in randomised trials of phytosomal curcumin versus placebo; waist/hip ratio pooled from 3 of 7 trials
Study record
- Design
- meta-analysis
- Species
- human
- Population
- Adults with nonalcoholic fatty liver disease, 7 RCTs, 443 participants
- Participants
- 443
- Comparator
- placebo
- Duration
- not reported
- Endpoints measured
- 7