Papers/PMID:39236662
Berberine as adjuvant therapy for treating reduced fertility potential in women with polycystic ovary syndrome: A meta-analysis of randomized controlled trials.
Explore (New York, N.Y.)2024The record
2 findings · 1 compound · 2 endpoints
What it reported
How to read these marksWhat moved
2 findings
berberine — increases clinical pregnancy rate
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Berberine in combination with Western medicine significantly improved endometrial thickness (weight mean difference [WMD] 1.62 mm; 95 % confidence interval [CI] 1.39-1.85), ovulation rate (risk ratio [RR] 1.41; 95 % CI 1.26-1.60), and clinical pregnancy rate (RR 1.96; 95 % CI 1.59-2.41) compared to Western medicine alone.”
Quoted verbatim from Berberine as adjuvant therapy for treating reduced fertility potential in women with polycystic ovary syndrome: A meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Population
- Women with polycystic ovary syndrome and reduced fertility potential; berberine added to Western medicine versus Western medicine alone (10 RCTs pooled)
Effect 1.96 risk ratio, 95% CI 1.59 to 2.41
Berberine as adjuvant therapy for treating reduced fertility potential in women with polycystic ovary syndrome: A meta-analysis of randomized controlled trials.2024PMID:39236662Permalink
berberine — decreases total testosterone
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Moreover, berberine as adjuvant therapy also significantly reduced the blood levels of luteinizing hormone (WMD -2.07 U/L; 95 % CI -2.62 to -1.51) and total testosterone (standard mean difference -0.70; 95 % CI -1.02 to -0.39) but not the level of follicle-stimulating hormone level (WMD -0.23 IU/L; 95 % CI -0.52 to 0.06).”
Quoted verbatim from Berberine as adjuvant therapy for treating reduced fertility potential in women with polycystic ovary syndrome: A meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Population
- Women with polycystic ovary syndrome and reduced fertility potential; berberine added to Western medicine versus Western medicine alone (10 RCTs pooled)
Effect -0.7 standardised mean difference, 95% CI -1.02 to -0.39
Berberine as adjuvant therapy for treating reduced fertility potential in women with polycystic ovary syndrome: A meta-analysis of randomized controlled trials.2024PMID:39236662Permalink