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PapersPMID:38274207

The metabolic effect of Momordica charantia cannot be determined based on the available clinical evidence: a systematic review and meta-analysis of randomized clinical trials.

Frontiers in nutrition2023The record ↗

findings
6
compound
1
endpoints
6
PMID:38274207
  1. Finding, moderate evidenceno difference foundHDL cholesterol
  2. Finding, moderate evidenceno difference foundLDL cholesterol
  3. Finding, moderate evidenceno difference foundTotal cholesterol (TC)
  4. Finding, moderate evidenceno difference foundTriglycerides
  5. Finding, moderate evidenceno difference foundSystolic blood pressure
  6. Finding, moderate evidenceno difference foundDiastolic blood pressure
Study, every finding
meta-analysis
Dose studied, every finding
daily dose 2–6 g fruit or extract of fruit equivalent to 9 g fruit

No finding here moved its endpoint.

What did not

How to read these marks →
  • “There was no evidence of significant effects of M. charantia on HDL (MD = −0.02; 95% CI: −0.12 to 0.09; I2 = 0%), LDL (MD = −0.01; 95% CI: −0.22 to 0.19; I2 = 0%), total cholesterol (MD = −0.04; 95% CI: −0.27 to 0.19; I2 = 0%) and triglyceride levels (MD = −0.09; 95% CI: −0.39 to 0.20; I2 = 22%) (Supplementary Figure S3).”
    • No detected effect on HDL cholesterol

      moderate

      Effect
      −0.02 mean difference, 95% CI −0.12 to 0.09
      Population
      Adults with prediabetes or type 2 diabetes in placebo-controlled randomised trials; analysis of post-intervention values
    • No detected effect on LDL cholesterol

      moderate

      Effect
      −0.01 mean difference, 95% CI −0.22 to 0.19
      Population
      Adults with prediabetes or type 2 diabetes in placebo-controlled randomised trials; analysis of post-intervention values
    • No detected effect on total cholesterol (TC)

      moderate

      Effect
      −0.04 mean difference, 95% CI −0.27 to 0.19
      Population
      Adults with prediabetes or type 2 diabetes in placebo-controlled randomised trials; analysis of post-intervention values
    • No detected effect on triglycerides

      moderate

      Effect
      −0.09 mean difference, 95% CI −0.39 to 0.2
      Population
      Adults with prediabetes or type 2 diabetes in placebo-controlled randomised trials; analysis of post-intervention values
  • “Administration of M. charantia fruits did not demonstrate any effect on systolic blood pressure (MD = 1.01; 95% CI: −1.07 to 3.09; I2 = 0%) or diastolic blood pressures (MD = 0.24; 95% CI: −1.04 to 1.53; I2 = 0%) when comparing the change scores to that of the placebo group.”
    • No detected effect on systolic blood pressure

      moderate

      Effect
      1.01 mean difference, 95% CI −1.07 to 3.09
      Population
      Adults with prediabetes or type 2 diabetes in placebo-controlled randomised trials; meta-analysis of change scores
    • No detected effect on diastolic blood pressure

      moderate

      Effect
      0.24 mean difference, 95% CI −1.04 to 1.53
      Population
      Adults with prediabetes or type 2 diabetes in placebo-controlled randomised trials; meta-analysis of change scores

Study record

Design
meta-analysis
Species
human
Population
adults with prediabetes or type 2 diabetes in nine randomized placebo-controlled trials of Momordica charantia fruit
Participants
414
Comparator
placebo
Duration
not reported
Endpoints measured
20