PapersPMID:37657523
Inulin-type fructans and 2'fucosyllactose alter both microbial composition and appear to alleviate stress-induced mood state in a working population compared to placebo (maltodextrin): the EFFICAD Trial, a randomized, controlled trial.
What moved
1 findingHow to read these marks →“Pairwise comparisons revealed BDI scores were significantly lower in the OF and OF/2’FL interventions compared with maltodextrin: OF (P ≤ 0.001; mean difference: −7.96; 95% CI: −12.03, −3.90); OF/2’FL (P ≤ 0.001; mean difference: −6.86; 95% CI: −10.93, −2.80).”
- Study
- RCT
- Duration
- 4 weeks
- Effect
- −7.96 mean difference, 95% CI −12.03 to −3.9
- Dose studied
- oligofructose 8 g/d plus 2 g/d maltodextrin, once daily in water with breakfast
- Population
- Healthy adults aged 18 to 50 in the UK with mild-to-moderately elevated stress and anxiety; 4-week intervention; oligofructose arm (8 g/d plus 2 g/d maltodextrin) against maltodextrin 10 g/d, day-28 ANCOVA contrast
Study record
- Design
- randomised controlled trial
- Species
- human
- Population
- Healthy adults aged 18 to 50, Reading UK, with mild/moderately elevated stress and anxiety (PHQ-9 and GAD-7); inulin-type fructan tested is oligofructose (Orafti P95), alone and with 2'fucosyllactose, against maltodextrin
- Participants
- 92
- Comparator
- placebo
- Duration
- 28 days
- Endpoints measured
- 102