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Catalyst

PapersPMID:36387924

Therapeutic effect and safety of curcumin in women with PCOS: A systematic review and meta-analysis.

Frontiers in endocrinology2022The record ↗

findings
4
compound
1
endpoints
4
no difference found
3
PMID:36387924
  1. Finding, moderate evidencelowersFasting blood glucose
  2. Finding, moderate evidenceno difference foundTriglycerides
  3. Finding, moderate evidenceno difference foundLDL cholesterol
  4. Finding, moderate evidenceno difference foundHDL cholesterol
Study, every finding
meta-analysis
Dose studied, every finding
curcumin 80 to 1500 mg/day (pooled); Curcuma longa water decoction 90 ml/day in some trials

What moved

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  • Decreases fasting blood glucose

    moderatereplicated ×6

    “As illustrated in significant decrease of PCOS patients’ FBG was observed after curcumin treatment comparing to that of the control group, there was a low degree of heterogeneity across the study data (WMD -3.618, 95% CI -5.165 to -2.071, P < 0.001, I2 = 20.4%).”
    Effect
    −3.618 mean difference, 95% CI −5.165 to −2.071
    Population
    Women with polycystic ovary syndrome (Rotterdam criteria) in 7 randomised trials; pooled curcumin or Curcuma longa water decoction against placebo, and curcumin plus metformin against metformin alone (metformin in both arms)

What did not

  • “The whole five data were pooled and significant improving effects of curcumin on triglycerides (TG) (WMD -8.889, 95% CI -27.246 to 9.468, P = 0.343, I2 = 91.5%), low-density lipoprotein cholesterol (LDL-C) (WMD -6.427, 95% CI -17.343 to 4.489, P = 0.249, I2 = 78.8%) and high-density lipoprotein cholesterol (HDL-C) (WMD 3.713, 95% CI -0.786 to 8.211, P = 0.106, I2 = 81.3%) were not identified compared to the control group.”
    • No detected effect on triglycerides

      moderatereplicated ×5

      Effect
      −8.889 mean difference, 95% CI −27.246 to 9.468
      Population
      Women with polycystic ovary syndrome in 5 pooled randomised trials; curcumin or Curcuma longa water decoction against placebo or metformin alone
    • No detected effect on LDL cholesterol

      moderatereplicated ×6

      Effect
      −6.427 mean difference, 95% CI −17.343 to 4.489
      Population
      Women with polycystic ovary syndrome in 5 pooled randomised trials; curcumin or Curcuma longa water decoction against placebo or metformin alone
    • No detected effect on HDL cholesterol

      moderatereplicated ×9

      Effect
      3.713 mean difference, 95% CI −0.786 to 8.211
      Population
      Women with polycystic ovary syndrome in 5 pooled randomised trials; curcumin or Curcuma longa water decoction against placebo or metformin alone

Study record

Design
meta-analysis
Species
human
Population
Women with PCOS (Rotterdam criteria) in 7 RCTs from Iran, Turkey and China; curcumin or Curcuma longa (CL) water decoction, alone or with metformin, versus placebo or metformin
Participants
447
Comparator
an active treatment / placebo
Duration
not reported
Endpoints measured
28