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Catalyst

PapersPMID:34559859

Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis.

PloS one2021The record ↗

  1. Finding, strong evidenceno difference foundPittsburgh Sleep Quality Index global score

No finding here moved its endpoint.

What did not

1 findingHow to read these marks →
  • “However, there was no significant effect of Ashwagandha extract compared to placebo in improving Pittsburgh Sleep Quality Index (SMD -0.90; 95% CI -2.13 to 0.33; I2 = 90%; p = 0.150; two trials; 131 participants), and total time in bed (SMD -0.17; 95% CI -0.41 to 0.07; I2 = 0%; p = 0.170; three trials; 281 participants).”
    Study
    meta-analysis
    Participants
    131
    Effect
    −0.9 standardised mean difference, 95% CI −2.13 to 0.33
    Dose studied
    600 mg/day (Table 1, the two trials reporting PSQI)
    Population
    Adults in randomised placebo-controlled trials pooled in a meta-analysis; PSQI reported by two of the five trials (one in adults with insomnia, one in healthy adults and adults with insomnia)

Study record

Design
meta-analysis
Species
human
Population
Adults 18 years and older, healthy or with DSM-IV insomnia, in five Indian RCTs of Withania somnifera extract versus placebo (KSM-66 root extract in four trials, Shoden root and leaf extract in one); one trial partially sponsored by the manufacturer
Participants
400
Comparator
placebo
Duration
not reported
Endpoints measured
20