Papers/PMID:34303665
Effect of resveratrol on inflammatory cytokines: A meta-analysis of randomized controlled trials.
European journal of pharmacology2021The record
2 findings · 1 compound · 2 endpoints
What it reported
How to read these marksWhat moved
2 findings
resveratrol — decreases tumour necrosis factor alpha concentration
PreliminaryGrade D, Preliminary. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1“Analysis in the overall population showed a significant effect of resveratrol consumption in reducing serum TNF-α levels (WMD = -0.66 pg/ml, 95% CI = -1.05 to -0.27, P = 0.001).”
Quoted verbatim from Effect of resveratrol on inflammatory cytokines: A meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Population
- Adults with inflammatory disease, overall pooled population across resveratrol RCTs (21 studies contributed to the TNF-α analysis per Methods).
Effect of resveratrol on inflammatory cytokines: A meta-analysis of randomized controlled trials.2021PMID:34303665Permalink
resveratrol — decreases interleukin-6 concentration
PreliminaryGrade D, Preliminary. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“A significant reduction of IL-6 concentration was observed only in the patients receiving ≥500 mg/day dose of resveratrol (WMD = -1.89 pg/ml, 95% CI = -3.73 to -0.05, P = 0.04) with inter-study heterogeneity (I2 = 94.4%, P < 0.001).”
Quoted verbatim from Effect of resveratrol on inflammatory cytokines: A meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Dose
- ≥500 mg/day (dose-stratified subgroup)
- Population
- Adults with inflammatory disease receiving ≥500 mg/day resveratrol (dose subgroup, one of 26 studies on IL-6 per Methods); the abstract does not report a significant result for the overall/lower-dose population.
Effect of resveratrol on inflammatory cytokines: A meta-analysis of randomized controlled trials.2021PMID:34303665Permalink