Papers/PMID:32974749
Intermittent leucine pulses during continuous feeding alters novel components involved in skeletal muscle growth of neonatal pigs.
Amino acids2020The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
L-leucine — is converted to 4-methyl-2-oxopentanoate
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“Compared with CON, LEU increased leucine and metabolites related to leucine catabolism, including 4-methyl-2-oxopentanoate, β-hydroxyisovalerate, β-hydroxyisovalerylcarnitine, and 3-methylglutaconate (P ≤ 0.05; Fig. 1c).”
Quoted verbatim from Intermittent leucine pulses during continuous feeding alters novel components involved in skeletal muscle growth of neonatal pigs.. - Study
- animal · not in humans
- Duration
- 3 weeks
- Dose
- 800 umol/kg BW/h intravenous for 1 h, six times per day, 21 days
- Population
- Neonatal pigs (7 days old) fed formula continuously for 21 days with intravenous leucine pulses (800 umol/kg/h, 1 h every 4 h) versus isonitrogenous alanine pulses; plasma metabolome 2 h into a pulse on day 18
Intermittent leucine pulses during continuous feeding alters novel components involved in skeletal muscle growth of neonatal pigs.2020PMID:32974749Industry fundedPermalink