Papers/PMID:31432995
Involvement of TLR4 in the protective effect of intra-articular administration of curcumin on rat experimental osteoarthritis.
Acta cirurgica brasileira2019The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
curcumin — inhibits TLR4
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“However, the increase in TLR4 expression induced by LPS was attenuated after intra-articular administration of curcumin (P<0.05; P<0.01).”
Quoted verbatim from Involvement of TLR4 in the protective effect of intra-articular administration of curcumin on rat experimental osteoarthritis.. - Study
- animal · not in humans
- Duration
- 8 weeks
- Dose
- 50 μl of 1 mg/mL curcumin intra-articular once a week for 8 weeks
- Population
- cartilage and synovium of rats with ACLT-induced osteoarthritis stimulated with intra-articular LPS; mRNA by real-time PCR and protein by western blot
Involvement of TLR4 in the protective effect of intra-articular administration of curcumin on rat experimental osteoarthritis.2019PMID:31432995Permalink