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PapersPMID:31388739

Effects of spirulina and wakame consumption on intestinal cholesterol absorption and serum lipid concentrations in non-hypercholesterolemic adult men and women.

European journal of nutrition2020The record ↗

findings
4
compound
1
endpoints
4
PMID:31388739
  1. Finding, moderate evidenceno difference foundHDL cholesterol
  2. Finding, moderate evidenceno difference foundTotal cholesterol (TC)
  3. Finding, moderate evidenceno difference foundBody mass
  4. Finding, moderate evidenceno difference foundLDL cholesterol
Study, every finding
crossover · 17 days
Dose studied, every finding
12 capsules of 400 mg spirulina daily (4.8 g/day), four capsules after each main meal, for 17 days

No finding here moved its endpoint.

What did not

How to read these marks →
  • “No differences were found between the spirulina and placebo conditions for serum total cholesterol (P = 0.443), LDL-C (P = 0.677), HDL-C (P = 0.273) and triacylglycerol concentrations (P = 0.684).”
    • No detected effect on HDL cholesterol

      moderatereplicated ×3

      Population
      35 healthy non-hypercholesterolaemic men and women (15 men, 20 women) aged 18-70, double-blind randomised three-period crossover (spirulina, wakame, placebo; 17 days each, washout at least 14 days); HDL-C by precipitation then CHOD-PAP
    • No detected effect on total cholesterol (TC)

      moderatereplicated ×2

      Population
      35 healthy non-hypercholesterolaemic men and women (15 men, 20 women) aged 18-70, double-blind randomised three-period crossover (spirulina, wakame, placebo; 17 days each, washout at least 14 days); serum total cholesterol by CHOD-PAP at the end of each period
    • No detected effect on LDL cholesterol

      moderatereplicated ×2

      Population
      35 healthy non-hypercholesterolaemic men and women (15 men, 20 women) aged 18-70, double-blind randomised three-period crossover (spirulina, wakame, placebo; 17 days each, washout at least 14 days); LDL-C calculated by the Friedewald formula, one subject excluded for triacylglycerol above the formula threshold
  • No detected effect on body mass

    moderatereplicated ×2

    “Changes in weight of the subjects did not differ between the spirulina (− 0.2 ± 0.7 kg), wakame (− 0.1 ± 0.6 kg) and placebo periods (− 0.2 ± 0.6 kg; P = 0.925 for treatment effect).”
    Population
    35 healthy non-hypercholesterolaemic men and women (15 men, 20 women) aged 18-70, double-blind randomised three-period crossover; change in body weight over each 17-day period

Study record

Design
crossover trial
Species
human
Population
apparently healthy non-hypercholesterolemic men and women aged 18 to 70 years, Maastricht, The Netherlands
Participants
35
Comparator
placebo
Duration
17 days
Endpoints measured
64