PapersPMID:27347994
Efficacy of Aloe Vera Supplementation on Prediabetes and Early Non-Treated Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- findings
- 5
- compound
- 1
- endpoints
- 5
- Study, every finding
- meta-analysis
What moved
How to read these marks →- Decreases fasting blood glucose
moderate
“Aloe vera was superior to placebo in reducing FBG levels (p = 0.02; WMD: −30.05 mg/dL; 95% CI: −54.87 to −5.23 mg/dL).”
- Effect
- −30.05 mean difference, 95% CI −54.87 to −5.23
- Population
- Adults with prediabetes or early non-treated diabetes mellitus, pooled across five randomized trials, mostly overweight or obese participants, follow-up 6 to 12 weeks
“After analysis of the aggregated results, we found that aloe vera was superior to placebo in reducing serum triglyceride and TC levels (p = 0.0001; WMD: −43.92 mg/dL; 95% CI: −66.33 to −21.51 mg/dL and p < 0.00001; WMD: −16.94 mg/dL; 95% CI: −23.39 to −10.50 mg/dL, respectively), although heterogeneity existed among these studies (p < 0.00001, I2 = 100% and p < 0.00001, I2 = 91%, respectively).”
- Decreases triglycerides
moderate
- Effect
- −43.92 mean difference, 95% CI −66.33 to −21.51
- Population
- Adults with prediabetes or early non-treated diabetes mellitus, pooled across four randomized trials, follow-up 6 to 12 weeks
- Decreases total cholesterol (TC)
moderate
- Effect
- −16.94 mean difference, 95% CI −23.39 to −10.5
- Population
- Adults with prediabetes or early non-treated diabetes mellitus, pooled across four randomized trials, follow-up 6 to 12 weeks
“Aloe vera was superior to placebo in increasing serum HDL-C levels (p = 0.04; WMD: 2.67 mg/dL; 95% CI: 0.11 to 5.23 mg/dL), and reducing serum LDL-C levels (p < 0.00001; WMD: −13.30 mg/dL; 95% CI: −17.19 to −9.41 mg/dL).”
- Increases HDL cholesterol
moderate
- Effect
- 2.67 mean difference, 95% CI 0.11 to 5.23
- Population
- Adults with prediabetes or early non-treated diabetes mellitus, pooled across three randomized trials, follow-up 6 to 12 weeks
- Decreases LDL cholesterol
moderate
- Effect
- −13.3 mean difference, 95% CI −17.19 to −9.41
- Population
- Adults with prediabetes or early non-treated diabetes mellitus, pooled across three randomized trials, follow-up 6 to 12 weeks
Study record
- Design
- meta-analysis
- Species
- human
- Population
- Prediabetes and early non-treated diabetic patients, mostly overweight or obese, in randomized controlled trials of aloe vera
- Participants
- 415
- Comparator
- placebo
- Duration
- not reported
- Endpoints measured
- 7