Papers/PMID:25475435
Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR Activation.
Diabetes2015The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
L-leucine — activates MTOR
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.Finding“The clamp-induced increases in p-mTORSer2448 and p-p70S6KThr389 were greater during whey protein and leucine ingestion relative to their respective control studies but not different during whey protein and leucine ingestion.”
Quoted verbatim from Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR Activation.. - Study
- crossover
- Dose
- 0.0684 g leucine per kg fat-free mass in 360 mL Kool-Aid, consumed in small aliquots every 20 min during the clamp
- Population
- Postmenopausal women, vastus muscle biopsies during a hyperinsulinemic-euglycemic clamp with and without leucine ingestion; phosphorylation read by Western blot
Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR Activation.2015PMID:25475435Industry fundedPermalink