Papers/PMID:25474484
Co-enzyme Q10 supplementation for the primary prevention of cardiovascular disease.
The Cochrane database of systematic reviews2014The record
4 findings · 1 compound · 4 endpoints · 4 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
4 findings
coenzyme Q10 — no detected effect on diastolic blood pressure (setting unspecified)
PreliminaryGrade D, Preliminary. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“For diastolic blood pressure we performed a random-effects meta-analysis, which showed no evidence of effect of CoQ10 supplementation when these two small trials were pooled (MD -1.62 mmHg, 95% CI -5.2 to 1.96).”
Quoted verbatim from Co-enzyme Q10 supplementation for the primary prevention of cardiovascular disease.. - Study
- meta-analysis
- Population
- adults at high risk of cardiovascular disease without a diagnosis of CVD; pooled analysis of two small RCTs
Effect -1.62 mean difference, 95% CI -5.2 to 1.96
Co-enzyme Q10 supplementation for the primary prevention of cardiovascular disease.2014PMID:25474484Permalink
coenzyme Q10 — no detected effect on total cholesterol (TC)
PreliminaryGrade D, Preliminary. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull resultreplicated ×2“The trial showed no evidence of effect of CoQ10 supplementation on total cholesterol (MD 0.30 mmol/L, 95% CI -0.10 to 0.70), high-density lipoprotein (HDL)-cholesterol (MD 0.02 mmol/L, 95% CI -0.13 to 0.17) or triglycerides (MD 0.05 mmol/L, 95% CI -0.42 to 0.52).”
Quoted verbatim from Co-enzyme Q10 supplementation for the primary prevention of cardiovascular disease.. - Study
- RCT
- Population
- adults at high risk of cardiovascular disease without a diagnosis of CVD; single RCT (51 patients randomised)
Effect 0.3 mean difference, 95% CI -0.1 to 0.7
Co-enzyme Q10 supplementation for the primary prevention of cardiovascular disease.2014PMID:25474484Permalink
coenzyme Q10 — no detected effect on HDL cholesterol
PreliminaryGrade D, Preliminary. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull resultreplicated ×3“The trial showed no evidence of effect of CoQ10 supplementation on total cholesterol (MD 0.30 mmol/L, 95% CI -0.10 to 0.70), high-density lipoprotein (HDL)-cholesterol (MD 0.02 mmol/L, 95% CI -0.13 to 0.17) or triglycerides (MD 0.05 mmol/L, 95% CI -0.42 to 0.52).”
Quoted verbatim from Co-enzyme Q10 supplementation for the primary prevention of cardiovascular disease.. - Study
- RCT
- Population
- adults at high risk of cardiovascular disease without a diagnosis of CVD; single RCT (51 patients randomised)
Effect 0.02 mean difference, 95% CI -0.13 to 0.17
Co-enzyme Q10 supplementation for the primary prevention of cardiovascular disease.2014PMID:25474484Permalink
coenzyme Q10 — no detected effect on triglycerides
PreliminaryGrade D, Preliminary. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull resultreplicated ×2“The trial showed no evidence of effect of CoQ10 supplementation on total cholesterol (MD 0.30 mmol/L, 95% CI -0.10 to 0.70), high-density lipoprotein (HDL)-cholesterol (MD 0.02 mmol/L, 95% CI -0.13 to 0.17) or triglycerides (MD 0.05 mmol/L, 95% CI -0.42 to 0.52).”
Quoted verbatim from Co-enzyme Q10 supplementation for the primary prevention of cardiovascular disease.. - Study
- RCT
- Population
- adults at high risk of cardiovascular disease without a diagnosis of CVD; single RCT (51 patients randomised)
Effect 0.05 mean difference, 95% CI -0.42 to 0.52
Co-enzyme Q10 supplementation for the primary prevention of cardiovascular disease.2014PMID:25474484Permalink