PapersPMID:23872591
MRI-measured regression of carotid atherosclerosis induced by statins with and without niacin in a randomised controlled trial: the NIA plaque study.
What moved
1 findingHow to read these marks →- Increases HDL cholesterol
moderate
“The net effect of the addition of niacin to statin therapy was a 17% relative increase in HDL (p<0.001 for the difference between groups).”
- Study
- RCT
- Duration
- 18 months
- Interests
- Industry funded
- Dose studied
- extended release niacin (Abbott) titrated to a target of 1500 mg daily over 12 weeks, added to statin; 88% of the niacin arm reached 1500 mg; comparator placebo plus statin
- Population
- Adults over 65 years with established atherosclerosis, all on statin therapy in both arms; 72 randomised to niacin and 73 to placebo
Study record
- Design
- randomised controlled trial
- Species
- human
- Population
- Older individuals (over age 65 years) with established atherosclerosis, all on statin therapy
- Participants
- 145
- Comparator
- placebo
- Duration
- 548 days
- Endpoints measured
- 25