Papers/PMID:23538007
Epigallocatechin-3-gallate is a potent phytochemical inhibitor of intimal hyperplasia in the wire-injured carotid artery.
Journal of vascular surgery2013The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
(-)-epigallocatechin 3-gallate — inhibits EPHB2
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“Western blot analysis confirmed diminished ERK activity in the EGCG-treated arteries, with a diminished phospho:total ERK ratio in the EGCG-treated arteries (P=.036, Mann-Whitney U test; Figure 4).”
Quoted verbatim from Epigallocatechin-3-gallate is a potent phytochemical inhibitor of intimal hyperplasia in the wire-injured carotid artery.. - Study
- animal · not in humans
- Duration
- 14 days
- Dose
- 1 mg/kg EGCG intraperitoneally daily from one day before surgery
- Population
- Wire-injured common carotid arteries of male Sprague-Dawley rats given daily intraperitoneal EGCG versus saline, harvested at 2 weeks
Epigallocatechin-3-gallate is a potent phytochemical inhibitor of intimal hyperplasia in the wire-injured carotid artery.2013PMID:23538007Permalink