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Catalyst

PapersPMID:23235581

Serenoa repens for benign prostatic hyperplasia.

The Cochrane database of systematic reviews2013The record ↗

findings
2
compound
1
endpoints
2
  1. Finding, very limited evidenceno difference foundInternational Prostate Symptom Score / AUA Symptom Index
  2. Finding, very limited evidenceno difference foundMaximum urinary flow rate (Qmax, peak flow)
Study, every finding
meta-analysis

No finding here moved its endpoint.

  • “In a meta-analysis of two high quality long-term trials (n = 582), Serenoa repens therapy was not superior to placebo in reducing LUTS based on the AUA (mean difference (MD) 0.25 points, 95% confidence interval (CI) -0.58 to 1.07).”
    Participants
    582
    Effect
    0.25 mean difference, 95% CI −0.58 to 1.07
    Population
    Men with lower urinary tract symptoms consistent with benign prostatic hyperplasia; pooled two high quality long-term trials
  • “The three high quality, moderate-to-long term trials found peak urine flow was not improved with Serenoa repens compared with placebo (MD 0.40 mL/s, 95% CI -0.30 to 1.09).”
    Effect
    0.4 mean difference, 95% CI −0.3 to 1.09
    Population
    Men with lower urinary tract symptoms consistent with benign prostatic hyperplasia; pooled three high quality moderate-to-long term trials

Study record

Design
meta-analysis
Species
human
Population
Men with symptomatic benign prostatic hyperplasia / LUTS; Serenoa repens preparations (alone or in combination) versus placebo or other interventions, 32 randomized trials
Participants
5,666
Comparator
placebo
Duration
not reported
Endpoints measured
6