PapersPMID:21187815
Anti-fatigue activity of extracts of stem bark from Acanthopanax senticosus.
- findings
- 2
- compound
- 1
- endpoints
- 2
- Study, every finding
- animal · not in humans · 4 weeks
- Dose studied, every finding
- 100, 200 or 400 mg/kg body weight once daily by gavage in 2.5 mL distilled water for four weeks
What moved
How to read these marks →- Increases time to exhaustion
insufficient
“As shown in Figure 2, the third group (middle-dose) and fourth (high-dose)group showed a significant increase swimming time to exhaustion compared with the first (control) group (P < 0.05).”
- Population
- Male Kunming mice after four weeks of daily gavage; forced swimming to exhaustion with a load of 10% of body weight; middle-dose (200 mg/kg) and high-dose (400 mg/kg) groups against distilled-water controls; the low-dose group (100 mg/kg) was longer but not significantly different
- Decreases blood urea nitrogen
insufficient
“As shown in Figure 4, after swimming, serum urea nitrogen (SUN) contents of the second (low-dose) group, the third group (middle-dose) and the fourth (high-dose) group were significantly lower than that of the first (control) group (P < 0.05).”
- Population
- Male Kunming mice after four weeks of daily gavage; serum urea nitrogen after 90 min of unloaded forced swimming and 1 h rest; all three ASSE dose groups (100, 200, 400 mg/kg) against distilled-water controls
Study record
- Design
- animal study, in vivo
- Species
- animal
- Population
- Male Kunming mice, 18–22 g, given water extract of Acanthopanax senticosus stem bark (ASSE) by gavage for four weeks
- Participants
- 120
- Comparator
- placebo
- Duration
- 28 days
- Endpoints measured
- 20