Proteins/UNIPROT:Q96AP4

ZUP1

ProteinUNIPROT:Q96AP4

Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains. Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage. Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress..

Function from UniProtKB (Q96AP4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

4 statements

4 statements · 2 reference databases · Subject: ZUP1 · Sources: gene ontology, Hetionet

Order

CLN8 interacts with ZUP1ProteinHetionet hetionet:interacts:2055-221302Inferred only
SHCBP1 interacts with ZUP1ProteinHetionet hetionet:interacts:221302-79801Inferred only
UBC interacts with ZUP1ProteinHetionet hetionet:interacts:221302-7316Inferred only
ZUP1 regulates regulation of DNA-templated transcriptionBiological processgene ontology Q96AP4|GO:0006355Inferred only

Other names

5 names

Resolves to: ZUP1

Also called: C6orf113DUBLys-63-specific deubiquitinase ZUFSPZinc finger with UFM1-specific peptidase domain proteinZUFSP

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