Proteins/UNIPROT:Q12836

ZP4

ProteinUNIPROT:Q12836

Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.

Function from UniProtKB (Q12836), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

8 statements

8 statements · 3 reference databases · Subject: ZP4 · Sources: gene ontology, Hetionet, Reactome

Order

FURIN interacts with ZP4ProteinHetionet hetionet:interacts:5045-57829Inferred only
ZP4 participates in FertilizationPathwayReactome R-HSA-1187000Inferred only
ZP4 participates in Interaction With Cumulus Cells And The Zona PellucidaPathwayReactome R-HSA-2534343Inferred only
ZP4 participates in ReproductionPathwayReactome R-HSA-1474165Inferred only
ZP4 regulates negative regulation of binding of sperm to zona pellucidaBiological processgene ontology Q12836|GO:2000360Inferred only
ZP4 regulates positive regulation of acrosome reactionBiological processgene ontology Q12836|GO:2000344Inferred only
ZP4 regulates positive regulation of humoral immune responseBiological processgene ontology Q12836|GO:0002922Inferred only
ZP4 regulates positive regulation of T cell proliferationBiological processgene ontology Q12836|GO:0042102Inferred only

Other names

5 names

Resolves to: ZP4

Also called: [Cleaved into: Processed zona pellucida sperm-binding protein 4]Zona pellucida glycoprotein 4Zona pellucida protein BZp-4ZPB

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