Proteins/UNIPROT:P21754

ZP3

ProteinUNIPROT:P21754

Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.

Function from UniProtKB (P21754), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

female infertility due to zona pellucida defect has a germline basis in ZP3DiseaseGenCC HGNC:13189|MONDO:0014342Inferred only
oocyte maturation defect 3 has a germline basis in ZP3DiseaseGenCC HGNC:13189|MONDO:0021574Inferred only

Statements

23 statements

23 statements · 4 reference databases · Subject: ZP3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

EDN2 covaries with ZP3ProteinHetionet hetionet:covaries:1907-7784Inferred only
ACR interacts with ZP3ProteinHetionet hetionet:interacts:49-7784Inferred only
FURIN interacts with ZP3ProteinHetionet hetionet:interacts:5045-7784Inferred only
ZP3 participates in 7q11 23 distal copy number variationPathwayWikiPathways WP5401Inferred only
ZP3 participates in FertilizationPathwayReactome R-HSA-1187000Inferred only
ZP3 participates in Interaction With Cumulus Cells And The Zona PellucidaPathwayReactome R-HSA-2534343Inferred only
ZP3 participates in Ovarian infertilityPathwayWikiPathways WP34Inferred only
ZP3 participates in Primary ovarian insufficiencyPathwayWikiPathways WP5461Inferred only
ZP3 participates in ReproductionPathwayReactome R-HSA-1474165Inferred only
ZP3 regulates negative regulation of binding of sperm to zona pellucidaBiological processgene ontology P21754|GO:2000360Inferred only
ZP3 regulates negative regulation of DNA-templated transcriptionBiological processgene ontology P21754|GO:0045892Inferred only
ZP3 regulates positive regulation of acrosomal vesicle exocytosisBiological processgene ontology P21754|GO:2000368Inferred only

Show the remaining 11

ZP3 regulates positive regulation of acrosome reactionBiological processgene ontology P21754|GO:2000344Inferred only
ZP3 regulates positive regulation of antral ovarian follicle growthBiological processgene ontology P21754|GO:2000388Inferred only
ZP3 regulates positive regulation of DNA-templated transcriptionBiological processgene ontology P21754|GO:0045893Inferred only
ZP3 regulates positive regulation of humoral immune responseBiological processgene ontology P21754|GO:0002922Inferred only
ZP3 regulates positive regulation of inflammatory responseBiological processgene ontology P21754|GO:0050729Inferred only
ZP3 regulates positive regulation of interleukin-4 productionBiological processgene ontology P21754|GO:0032753Inferred only
ZP3 regulates positive regulation of leukocyte migrationBiological processgene ontology P21754|GO:0002687Inferred only
ZP3 regulates positive regulation of ovarian follicle developmentBiological processgene ontology P21754|GO:2000386Inferred only
ZP3 regulates positive regulation of T cell proliferationBiological processgene ontology P21754|GO:0042102Inferred only
ZP3 regulates positive regulation of type II interferon productionBiological processgene ontology P21754|GO:0032729Inferred only
ZP3 regulates positive regulation of type IV hypersensitivityBiological processgene ontology P21754|GO:0001809Inferred only

Other names

9 names

Resolves to: ZP3

Also called: [Cleaved into: Processed zona pellucida sperm-binding protein 3]Sperm receptorZona pellucida glycoprotein 3Zona pellucida protein CZp-3ZP3AZP3A/ZP3BZP3BZPC

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