Proteins/UNIPROT:P60852

ZP1

ProteinUNIPROT:P60852

Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.

Function from UniProtKB (P60852), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

female infertility due to zona pellucida defect has a germline basis in ZP1DiseaseGenCC HGNC:13187|MONDO:0014342Inferred only

Statements

4 statements

4 statements · 2 reference databases · Subject: ZP1 · Sources: Hetionet, Reactome

Order

CLEC4E covaries with ZP1ProteinHetionet hetionet:covaries:22917-26253Inferred only
ZP1 participates in FertilizationPathwayReactome R-HSA-1187000Inferred only
ZP1 participates in Interaction With Cumulus Cells And The Zona PellucidaPathwayReactome R-HSA-2534343Inferred only
ZP1 participates in ReproductionPathwayReactome R-HSA-1474165Inferred only

Other names

3 names

Resolves to: ZP1

Also called: [Cleaved into: Processed zona pellucida sperm-binding protein 1]Zona pellucida glycoprotein 1Zp-1

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