Proteins/UNIPROT:Q3ZCX4

ZNF568

ProteinUNIPROT:Q3ZCX4

Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but also has repression activity independently of this interaction. Essential during embryonic development, where it acts as a direct repressor of a placental-specific transcript of IGF2 in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance proliferation or maintenance of neural stem cells..

Function from UniProtKB (Q3ZCX4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

9 statements

9 statements · 3 reference databases · Subject: ZNF568 · Sources: gene ontology, Hetionet, Reactome

Order

ZNF568 covaries with TMEM205ProteinHetionet hetionet:covaries:374882-374900Inferred only
ZNF568 covaries with TPM4ProteinHetionet hetionet:covaries:374900-7171Inferred only
ZNF7 covaries with ZNF568ProteinHetionet hetionet:covaries:374900-7553Inferred only
ZNF568 participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
ZNF568 participates in Generic Transcription PathwayPathwayReactome R-HSA-212436Inferred only
ZNF568 participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only
ZNF568 regulates negative regulation of DNA-templated transcriptionBiological processgene ontology Q3ZCX4|GO:0045892Inferred only
ZNF568 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q3ZCX4|GO:0000122Inferred only
ZNF568 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q3ZCX4|GO:0006357Inferred only

Other names

1 name

Resolves to: ZNF568

Also called: Zinc finger protein 568

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