Proteins/UNIPROT:Q92618

ZNF516

ProteinUNIPROT:Q92618

Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress..

Function from UniProtKB (Q92618), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

19 statements

19 statements · 3 reference databases · Subject: ZNF516 · Sources: gene ontology, Hetionet, WikiPathways

Order

ZNF516 covaries with CAPN10ProteinHetionet hetionet:covaries:11132-9658Inferred only
ZNF516 covaries with CDK11BProteinHetionet hetionet:covaries:9658-984Inferred only
ZNF516 covaries with IGHMBP2ProteinHetionet hetionet:covaries:3508-9658Inferred only
ZNF516 covaries with LIG1ProteinHetionet hetionet:covaries:3978-9658Inferred only
ZNF516 covaries with MYO1GProteinHetionet hetionet:covaries:64005-9658Inferred only
ZNF516 covaries with NSMCE3ProteinHetionet hetionet:covaries:56160-9658Inferred only
ZNF516 covaries with PLCH2ProteinHetionet hetionet:covaries:9651-9658Inferred only
ZNF516 covaries with RGS12ProteinHetionet hetionet:covaries:6002-9658Inferred only
ZNF516 covaries with SALL3ProteinHetionet hetionet:covaries:27164-9658Inferred only
ZNF516 covaries with TBXTProteinHetionet hetionet:covaries:6862-9658Inferred only
ZNF516 covaries with TRAF2ProteinHetionet hetionet:covaries:7186-9658Inferred only
ZNF516 covaries with TSHZ1ProteinHetionet hetionet:covaries:10194-9658Inferred only

Show the remaining 7

ZNF516 covaries with ZFP41ProteinHetionet hetionet:covaries:286128-9658Inferred only
H3-4 interacts with ZNF516ProteinHetionet hetionet:interacts:8290-9658Inferred only
ZNF516 participates in ThermogenesisPathwayWikiPathways WP4321Inferred only
ZNF516 participates in Thyroid hormones production and peripheral downstream signaling effectsPathwayWikiPathways WP4746Inferred only
ZNF516 regulates positive regulation of cold-induced thermogenesisBiological processgene ontology Q92618|GO:0120162Inferred only
ZNF516 regulates positive regulation of DNA-templated transcriptionBiological processgene ontology Q92618|GO:0045893Inferred only
ZNF516 regulates regulation of DNA-templated transcriptionBiological processgene ontology Q92618|GO:0006355Inferred only

Other names

2 names

Resolves to: ZNF516

Also called: KIAA0222Zinc finger protein 516

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