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Proteins/UNIPROT:Q9NZL3

ZNF224

Protein·UNIPROT:Q9NZL3

Open in the graph

May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells..

Function from UniProtKB (Q9NZL3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

11 statements

11 statements · 3 reference databases · Subject: ZNF224 · Sources: gene ontology, Hetionet, Reactome

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ZNF224 interacts with PRMT5ProteinHetionet hetionet:interacts:10419-7767Inferred only
ZNF224 interacts with TRIM28ProteinHetionet hetionet:interacts:10155-7767Inferred only
ZNF224 participates in Epigenetic regulation of gene expressionPathwayReactome R-HSA-212165Inferred only
ZNF224 participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
ZNF224 participates in Generic Transcription PathwayPathwayReactome R-HSA-212436Inferred only
ZNF224 participates in Regulation of endogenous retroelementsPathwayReactome R-HSA-9842860Inferred only
ZNF224 participates in Regulation of endogenous retroelements by KRAB-ZFP proteinsPathwayReactome R-HSA-9843940Inferred only
ZNF224 participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only
ZNF224 regulates negative regulation of DNA-templated transcriptionBiological processgene ontology Q9NZL3|GO:0045892Inferred only
ZNF224 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q9NZL3|GO:0000122Inferred only
ZNF224 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q9NZL3|GO:0006357Inferred only

Other names

11 names

Resolves to: ZNF224

Also called: BMZF-2BMZF2Bone marrow zinc finger 2KOX22Zinc finger protein 233Zinc finger protein 255Zinc finger protein 27Zinc finger protein KOX22ZNF233ZNF255ZNF27

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