Proteins/UNIPROT:Q9NQZ6

ZC4H2

ProteinUNIPROT:Q9NQZ6

Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Involved in neuronal development and in neuromuscular junction formation. Binds Zn(2+) ion with high affinity. The RNF220/ZC4H2 complex monoubiquitinates PHOX2A and PHOX2B to enhance their DNA-binding ability and transactivity (By similarity)..

Function from UniProtKB (Q9NQZ6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

Wieacker-Wolff syndrome has a germline basis in ZC4H2DiseaseGenCC HGNC:24931|MONDO:0010758Inferred only
Wieacker-Wolff syndrome, female-restricted has a germline basis in ZC4H2DiseaseGenCC HGNC:24931|MONDO:0026762Inferred only
X-linked syndromic intellectual disability has a germline basis in ZC4H2DiseaseGenCC HGNC:24931|MONDO:0020119Inferred only

Statements

5 statements

5 statements · 2 reference databases · Subject: ZC4H2 · Sources: gene ontology, Hetionet

Order

ZC4H2 interacts with KXD1ProteinHetionet hetionet:interacts:55906-79036Inferred only
PIK3R1 interacts with ZC4H2ProteinHetionet hetionet:interacts:5295-55906Inferred only
ZC4H2 regulates positive regulation of neuron differentiationBiological processgene ontology Q9NQZ6|GO:0045666Inferred only
ZC4H2 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q9NQZ6|GO:0045944Inferred only
ZC4H2 regulates regulation of transcription regulatory region DNA bindingBiological processgene ontology Q9NQZ6|GO:2000677Inferred only

Other names

4 names

Resolves to: ZC4H2

Also called: HCA127Hepatocellular carcinoma-associated antigen 127KIAA1166Zinc finger C4H2 domain-containing protein

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