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Proteins/UNIPROT:Q8N5P1

ZC3H8

Protein·UNIPROT:Q8N5P1

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Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis..

Function from UniProtKB (Q8N5P1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

11 statements

11 statements · 4 reference databases · Subject: ZC3H8 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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CSNK2A1 interacts with ZC3H8ProteinHetionet hetionet:interacts:1457-84524Inferred only
ZC3H8 participates in 2q13 copy number variation syndromePathwayWikiPathways WP5222Inferred only
ZC3H8 participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
ZC3H8 participates in RNA polymerase II transcribes snRNA genesPathwayReactome R-HSA-6807505Inferred only
ZC3H8 participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only
ZC3H8 regulates negative regulation of DNA-templated transcriptionBiological processgene ontology Q8N5P1|GO:0045892Inferred only
ZC3H8 regulates negative regulation of DNA-templated transcription, elongationBiological processgene ontology Q8N5P1|GO:0032785Inferred only
ZC3H8 regulates negative regulation of T cell differentiation in thymusBiological processgene ontology Q8N5P1|GO:0033085Inferred only
ZC3H8 regulates positive regulation of snRNA transcription by RNA polymerase IIBiological processgene ontology Q8N5P1|GO:1905382Inferred only
ZC3H8 regulates positive regulation of thymocyte apoptotic processBiological processgene ontology Q8N5P1|GO:0070245Inferred only
ZC3H8 regulates positive regulation of transcription by RNA polymerase IIIBiological processgene ontology Q8N5P1|GO:0045945Inferred only

Other names

2 names

Resolves to: ZC3H8

Also called: ZC3HDC8Zinc finger CCCH domain-containing protein 8

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