Proteins/UNIPROT:Q8IWB7

WDFY1

ProteinUNIPROT:Q8IWB7

Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines..

Function from UniProtKB (Q8IWB7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

6 statements

6 statements · 3 reference databases · Subject: WDFY1 · Sources: gene ontology, Hetionet, WikiPathways

Order

KRTAP13-1 covaries with WDFY1ProteinHetionet hetionet:covaries:140258-57590Inferred only
WDFY1 participates in miR targeted genes in leukocytesPathwayWikiPathways WP2003Inferred only
WDFY1 participates in miR targeted genes in lymphocytesPathwayWikiPathways WP2004Inferred only
WDFY1 participates in miR targeted genes in muscle cellPathwayWikiPathways WP2005Inferred only
WDFY1 regulates positive regulation of toll-like receptor 3 signaling pathwayBiological processgene ontology Q8IWB7|GO:0034141Inferred only
WDFY1 regulates positive regulation of toll-like receptor 4 signaling pathwayBiological processgene ontology Q8IWB7|GO:0034145Inferred only

Other names

9 names

Resolves to: WDFY1

Also called: FENS-1FENS1FYVE domain-containing protein localized to endosomes 1KIAA1435Phosphoinositide-binding protein 1WD40- and FYVE domain-containing protein 1WDF1ZFYVE17Zinc finger FYVE domain-containing protein 17

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