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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q9Y279

VSIG4

Protein·UNIPROT:Q9Y279

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Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases..

Function from UniProtKB (Q9Y279), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

9 statements

9 statements · 3 reference databases · Subject: VSIG4 · Sources: gene ontology, Hetionet, WikiPathways

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VSIG4 covaries with SMARCC2ProteinHetionet hetionet:covaries:11326-6601Inferred only
APP interacts with VSIG4ProteinHetionet hetionet:interacts:11326-351Inferred only
C3 interacts with VSIG4ProteinHetionet hetionet:interacts:11326-718Inferred only
PDK2 interacts with VSIG4ProteinHetionet hetionet:interacts:11326-5164Inferred only
VSIG4 participates in Complement systemPathwayWikiPathways WP2806Inferred only
VSIG4 regulates negative regulation of complement activation, alternative pathwayBiological processgene ontology Q9Y279|GO:0045957Inferred only
VSIG4 regulates negative regulation of interleukin-2 productionBiological processgene ontology Q9Y279|GO:0032703Inferred only
VSIG4 regulates negative regulation of macrophage activationBiological processgene ontology Q9Y279|GO:0043031Inferred only
VSIG4 regulates negative regulation of T cell proliferationBiological processgene ontology Q9Y279|GO:0042130Inferred only

Other names

4 names

Resolves to: VSIG4

Also called: CRIgProtein Z39IgV-set and immunoglobulin domain-containing protein 4Z39IG

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