Proteins/UNIPROT:Q8IWX7

UNC45B

ProteinUNIPROT:Q8IWX7

Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. Is necessary for normal early lens development..

Function from UniProtKB (Q8IWX7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

4 rows

cataract 43 has a germline basis in UNC45BDiseaseGenCC HGNC:14304|MONDO:0014565Inferred only
early-onset nuclear cataract has a germline basis in UNC45BDiseaseGenCC HGNC:14304|MONDO:0020376Inferred only
early-onset posterior subcapsular cataract has a germline basis in UNC45BDiseaseGenCC HGNC:14304|MONDO:0018610Inferred only
myofibrillar myopathy 11 has a germline basis in UNC45BDiseaseGenCC HGNC:14304|MONDO:0030927Inferred only

Statements

8 statements

8 statements · 2 reference databases · Subject: UNC45B · Sources: Hetionet, WikiPathways

Order

UNC45B participates in 17q12 copy number variation syndromePathwayWikiPathways WP5287Inferred only
UNC45B decreases the expression of ATP6V0BProteinHetionet hetionet:regulates:146862-533Inferred only
UNC45B decreases the expression of CD44ProteinHetionet hetionet:regulates:146862-960Inferred only
UNC45B increases the expression of CNPY3ProteinHetionet hetionet:regulates:146862-10695Inferred only
UNC45B increases the expression of GPER1ProteinHetionet hetionet:regulates:146862-2852Inferred only
UNC45B decreases the expression of NUP93ProteinHetionet hetionet:regulates:146862-9688Inferred only
UNC45B increases the expression of TRIM13ProteinHetionet hetionet:regulates:146862-10206Inferred only
UNC45B decreases the expression of USP22ProteinHetionet hetionet:regulates:146862-23326Inferred only

Other names

4 names

Resolves to: UNC45B

Also called: CMYA4SMUNC45Unc-45BUNC45

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