Proteins/UNIPROT:Q96C45

ULK4

ProteinUNIPROT:Q96C45

Pseudokinase that acts as a molecular adapter in the smoothened signaling pathway. Required to relieve inhibition of the GLI2 transcription factor in the presence of hedgehog (DHH, IHH or SHH) ligand: acts by mediating the association between STK36 and its ligand GLI2 in ciliary tip, promoting GLI2 phosphorylation and dissociation from SUFU inhibitor, followed by GLI2 translocation to the nucleus..

Function from UniProtKB (Q96C45), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

11 statements

11 statements · 2 reference databases · Subject: ULK4 · Sources: gene ontology, Hetionet

Order

APP interacts with ULK4ProteinHetionet hetionet:interacts:351-54986Inferred only
ULK4 interacts with SMURF1ProteinHetionet hetionet:interacts:54986-57154Inferred only
YWHAQ interacts with ULK4ProteinHetionet hetionet:interacts:10971-54986Inferred only
ULK4 regulates positive regulation of smoothened signaling pathwayBiological processgene ontology Q96C45|GO:0045880Inferred only
ULK4 regulates regulation of JNK cascadeBiological processgene ontology Q96C45|GO:0046328Inferred only
ULK4 regulates regulation of MAPK cascadeBiological processgene ontology Q96C45|GO:0043408Inferred only
ULK4 regulates regulation of neuron migrationBiological processgene ontology Q96C45|GO:2001222Inferred only
ULK4 regulates regulation of neuron projection developmentBiological processgene ontology Q96C45|GO:0010975Inferred only
ULK4 regulates regulation of p38MAPK cascadeBiological processgene ontology Q96C45|GO:1900744Inferred only
ULK4 decreases the expression of CDKN1BProteinHetionet hetionet:regulates:54986-1027Inferred only
ULK4 increases the expression of GPX3ProteinHetionet hetionet:regulates:54986-2878Inferred only

Other names

2 names

Resolves to: ULK4

Also called: Pseudokinase ULK4Unc-51-like kinase 4

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