Proteins/UNIPROT:P68543

UBXN2A

ProteinUNIPROT:P68543

Acts to repress the ubiquitination and subsequent endoplasmic reticulum-associated degradation of CHRNA3 by the STUB1-VCP-UBXN2A complex in cortical neurons. Also acts to promote the translocation of CHRNA3 to the plasma membrane and subsequently increases plasma membrane acetylcholine-gated ion-channel activation (By similarity). Plays a role in the inhibition of STUB1-mediated TP53 degradation, via its interaction with HSPA9 which acts to inhibit TP53 binding to HSPA9. Positively mediates the ubiquitination and proteosomal degradation of RICTOR, may thereby act as a negative regulator of the mTORC2 pathway..

Function from UniProtKB (P68543), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

8 statements

8 statements · 2 reference databases · Subject: UBXN2A · Sources: gene ontology, Hetionet

Order

UBXN2A covaries with PPP1R12CProteinHetionet hetionet:covaries:165324-54776Inferred only
DBI interacts with UBXN2AProteinHetionet hetionet:interacts:1622-165324Inferred only
PHAX interacts with UBXN2AProteinHetionet hetionet:interacts:165324-51808Inferred only
UBC interacts with UBXN2AProteinHetionet hetionet:interacts:165324-7316Inferred only
VCP interacts with UBXN2AProteinHetionet hetionet:interacts:165324-7415Inferred only
UBXN2A regulates negative regulation of ERAD pathwayBiological processgene ontology P68543|GO:1904293Inferred only
UBXN2A regulates negative regulation of proteolysisBiological processgene ontology P68543|GO:0045861Inferred only
UBXN2A regulates positive regulation of protein catabolic processBiological processgene ontology P68543|GO:0045732Inferred only

Other names

3 names

Resolves to: UBXN2A

Also called: UBX domain-containing protein 2AUBX domain-containing protein 4UBXD4

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