Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:Q7Z6J8

UBE3D

Protein·UNIPROT:Q7Z6J8

Open in the graph

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Independently of its E3 ubiquitin-protein ligase activity, acts as an inhibitor of CPSF3 endonuclease activity by blocking CPSF3 active site..

Function from UniProtKB (Q7Z6J8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

7 statements

7 statements · 2 reference databases · Subject: UBE3D · Sources: Hetionet, Reactome

Search this listOrder

CCNB1 interacts with UBE3DProteinHetionet hetionet:interacts:891-90025Inferred only
UBC interacts with UBE3DProteinHetionet hetionet:interacts:7316-90025Inferred only
UBE2C interacts with UBE3DProteinHetionet hetionet:interacts:11065-90025Inferred only
UBE3D participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
UBE3D participates in Antigen processing: Ubiquitination & Proteasome degradationPathwayReactome R-HSA-983168Inferred only
UBE3D participates in Class I MHC mediated antigen processing & presentationPathwayReactome R-HSA-983169Inferred only
UBE3D participates in Immune SystemPathwayReactome R-HSA-168256Inferred only

Other names

6 names

Resolves to: UBE3D

Also called: C6orf157H10BHHECT-type E3 ubiquitin transferase E3DUbcH10-binding protein with a HECT-like domainUBE2CBPUbiquitin-conjugating enzyme E2C-binding protein

← Every protein Find it in the graph →