Proteins/UNIPROT:Q96RT7

TUBGCP6

ProteinUNIPROT:Q96RT7

Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation..

Function from UniProtKB (Q96RT7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

microcephaly and chorioretinopathy 1 has a germline basis in TUBGCP6DiseaseGenCC HGNC:18127|MONDO:0009624Inferred only

Statements

19 statements

19 statements · 3 reference databases · Subject: TUBGCP6 · Sources: Hetionet, Reactome, WikiPathways

Order

TUBGCP6 covaries with DIPK1CProteinHetionet hetionet:covaries:125704-85378Inferred only
GTSE1 covaries with TUBGCP6ProteinHetionet hetionet:covaries:51512-85378Inferred only
TUBGCP6 covaries with LDLRAD4ProteinHetionet hetionet:covaries:753-85378Inferred only
TUBGCP6 covaries with OPTCProteinHetionet hetionet:covaries:26254-85378Inferred only
PASK covaries with TUBGCP6ProteinHetionet hetionet:covaries:23178-85378Inferred only
TUBGCP6 covaries with RSRP1ProteinHetionet hetionet:covaries:57035-85378Inferred only
SELENOO covaries with TUBGCP6ProteinHetionet hetionet:covaries:83642-85378Inferred only
UBC interacts with TUBGCP6ProteinHetionet hetionet:interacts:7316-85378Inferred only
TUBGCP6 participates in 15q11 2 copy number variation syndromePathwayWikiPathways WP4940Inferred only
TUBGCP6 participates in Cell CyclePathwayReactome R-HSA-1640170Inferred only
TUBGCP6 participates in Cell Cycle, MitoticPathwayReactome R-HSA-69278Inferred only
TUBGCP6 participates in Centrosome maturationPathwayReactome R-HSA-380287Inferred only

Show the remaining 7

TUBGCP6 participates in G2/M TransitionPathwayReactome R-HSA-69275Inferred only
TUBGCP6 participates in M PhasePathwayReactome R-HSA-68886Inferred only
TUBGCP6 participates in Mitotic G2-G2/M phasesPathwayReactome R-HSA-453274Inferred only
TUBGCP6 participates in Mitotic PrometaphasePathwayReactome R-HSA-68877Inferred only
TUBGCP6 participates in Prader Willi and Angelman syndromePathwayWikiPathways WP3998Inferred only
TUBGCP6 participates in Recruitment of mitotic centrosome proteins and complexesPathwayReactome R-HSA-380270Inferred only
TUBGCP6 participates in Recruitment of NuMA to mitotic centrosomesPathwayReactome R-HSA-380320Inferred only

Other names

4 names

Resolves to: TUBGCP6

Also called: Gamma-tubulin complex component 6GCP-6GCP6KIAA1669

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